{"title":"握力与认知/痴呆风险的因果关系：一项孟德尔随机研究。","authors":"Qian Sun, Qian Cao, Zhen Gu, Peicheng He, Minmin Zhu, Xiao Liang","doi":"10.62347/LBNH3951","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Muscle strength positively correlates with cognitive function, with the bidirectional causal link between hand grip strength and cognition posing a significant but incompletely understood public health challenge. This study aimed to explore the causal relationship between hand grip strength and cognition and its effect on dementia.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization analysis used genome-wide significant single nucleotide polymorphisms (SNPs) (P < 5×10<sup>-8</sup>, at least P < 5×10<sup>-6</sup>) linked to hand grip strength (right or left), cognition/dementia risk from the IEU Open GWAS project with 42,484 GWAS summary data sets. The primary analysis employed the inverse variance weighted method, while sensitivity analyses were conducted using the weighted mode and MR-Egger. These analyses aimed to assess the causal relationships between hand grip strength and cognition/dementia risk.</p><p><strong>Results: </strong>The inverse variance weighted (IVW) analysis indicated a directional positive causal effects of hand grip strength on cognition (Left-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.026)/performance (OR (95% Cl): 1.16 (1.04-1.30), P = 0.009); Right-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.031)/performance (OR (95% Cl): 1.10 (1.02-1.19), P = 0.018), with almost no reverse causality between cognitive function/performance and hand grip strength. Based on the results above, we then researched the directional causal effects of hand grip strength on neurodegenerative diseases (like dementia) with cognitive decline as the main clinical manifestation. However, the IVW methods yielded no evidence to support a causal effect of left-hand grip strength on dementia (P > 0.05).</p><p><strong>Conclusions: </strong>This MR study indicates a positive directional causal relationship between hand grip strength and cognition, with no observed causal link to dementia. These results hold implications for the development of public health measures and strategies for preventing cognitive decline.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 3","pages":"1910-1924"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982891/pdf/","citationCount":"0","resultStr":"{\"title\":\"Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.\",\"authors\":\"Qian Sun, Qian Cao, Zhen Gu, Peicheng He, Minmin Zhu, Xiao Liang\",\"doi\":\"10.62347/LBNH3951\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Muscle strength positively correlates with cognitive function, with the bidirectional causal link between hand grip strength and cognition posing a significant but incompletely understood public health challenge. This study aimed to explore the causal relationship between hand grip strength and cognition and its effect on dementia.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization analysis used genome-wide significant single nucleotide polymorphisms (SNPs) (P < 5×10<sup>-8</sup>, at least P < 5×10<sup>-6</sup>) linked to hand grip strength (right or left), cognition/dementia risk from the IEU Open GWAS project with 42,484 GWAS summary data sets. The primary analysis employed the inverse variance weighted method, while sensitivity analyses were conducted using the weighted mode and MR-Egger. These analyses aimed to assess the causal relationships between hand grip strength and cognition/dementia risk.</p><p><strong>Results: </strong>The inverse variance weighted (IVW) analysis indicated a directional positive causal effects of hand grip strength on cognition (Left-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.026)/performance (OR (95% Cl): 1.16 (1.04-1.30), P = 0.009); Right-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.031)/performance (OR (95% Cl): 1.10 (1.02-1.19), P = 0.018), with almost no reverse causality between cognitive function/performance and hand grip strength. Based on the results above, we then researched the directional causal effects of hand grip strength on neurodegenerative diseases (like dementia) with cognitive decline as the main clinical manifestation. However, the IVW methods yielded no evidence to support a causal effect of left-hand grip strength on dementia (P > 0.05).</p><p><strong>Conclusions: </strong>This MR study indicates a positive directional causal relationship between hand grip strength and cognition, with no observed causal link to dementia. These results hold implications for the development of public health measures and strategies for preventing cognitive decline.</p>\",\"PeriodicalId\":7731,\"journal\":{\"name\":\"American journal of translational research\",\"volume\":\"17 3\",\"pages\":\"1910-1924\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982891/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of translational research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.62347/LBNH3951\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/LBNH3951","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
背景：肌肉力量与认知功能正相关，握力与认知之间的双向因果关系构成了一个重要但尚未完全理解的公共卫生挑战。本研究旨在探讨握力与认知的因果关系及其对痴呆的影响。方法：采用双样本孟德尔随机化分析，使用全基因组显著单核苷酸多态性（snp） （P < 5×10-8，至少P < 5×10-6）与握力（右或左）、认知/痴呆风险相关，来自IEU Open GWAS项目的42,484个GWAS汇总数据集。初步分析采用方差反加权法，敏感性分析采用加权模型和MR-Egger法。这些分析旨在评估握力与认知/痴呆风险之间的因果关系。结果：反方差加权（IVW）分析显示，握力对认知(左手握力对认知功能(OR (95% Cl): 1.23 (1.02-1.48), P = 0.026)/表现(OR （95% Cl): 1.16 (1.04-1.30), P = 0.009）有正向正向的影响；右手握力对认知功能(OR (95% Cl): 1.23 (1.02-1.48), P = 0.031)/表现(OR （95% Cl): 1.10 (1.02-1.19), P = 0.018）的影响，认知功能/表现与右手握力之间几乎没有反向因果关系。在此基础上，我们进一步研究了手握力对以认知能力下降为主要临床表现的神经退行性疾病（如痴呆）的定向因果效应。然而，IVW方法没有证据支持左手握力对痴呆的因果影响（P < 0.05）。结论：这项MR研究表明，握力和认知之间存在正向因果关系，与痴呆没有观察到的因果关系。这些结果对预防认知能力下降的公共卫生措施和策略的发展具有启示意义。
Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.
Background: Muscle strength positively correlates with cognitive function, with the bidirectional causal link between hand grip strength and cognition posing a significant but incompletely understood public health challenge. This study aimed to explore the causal relationship between hand grip strength and cognition and its effect on dementia.
Methods: A two-sample Mendelian randomization analysis used genome-wide significant single nucleotide polymorphisms (SNPs) (P < 5×10-8, at least P < 5×10-6) linked to hand grip strength (right or left), cognition/dementia risk from the IEU Open GWAS project with 42,484 GWAS summary data sets. The primary analysis employed the inverse variance weighted method, while sensitivity analyses were conducted using the weighted mode and MR-Egger. These analyses aimed to assess the causal relationships between hand grip strength and cognition/dementia risk.
Results: The inverse variance weighted (IVW) analysis indicated a directional positive causal effects of hand grip strength on cognition (Left-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.026)/performance (OR (95% Cl): 1.16 (1.04-1.30), P = 0.009); Right-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.031)/performance (OR (95% Cl): 1.10 (1.02-1.19), P = 0.018), with almost no reverse causality between cognitive function/performance and hand grip strength. Based on the results above, we then researched the directional causal effects of hand grip strength on neurodegenerative diseases (like dementia) with cognitive decline as the main clinical manifestation. However, the IVW methods yielded no evidence to support a causal effect of left-hand grip strength on dementia (P > 0.05).
Conclusions: This MR study indicates a positive directional causal relationship between hand grip strength and cognition, with no observed causal link to dementia. These results hold implications for the development of public health measures and strategies for preventing cognitive decline.
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