脂质：线粒体蛋白输入中的新角色。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-04-15 DOI:10.1016/j.tibs.2025.03.011

Mayra A Borrero-Landazabal, Vanessa Linke, Agnieszka Chacinska

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引用次数: 0

摘要

脂质正在成为线粒体蛋白进口的功能参与者，而不是构成膜。蛋白质转位酶（如外膜转位酶（TOM））和插入酶（如内膜转位酶（TIM22））的低温电子显微镜结构将脂质与蛋白质进口联系起来，表明脂质在蛋白质易位和插入中的结构和功能作用，以及蛋白质插入酶在脂质混乱中的作用。

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Lipids: emerging actors in mitochondrial protein import.

Lipids are emerging as functional players in mitochondrial protein import beyond constituting membranes. Cryo-electron microscopy structures of protein translocases such as translocase of the outer membrane (TOM) and insertases such as translocase of the inner membrane (TIM22) link lipids to protein import by suggesting structural and functional roles for lipids in protein translocation and insertion, and for protein insertases in lipid scrambling.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.