光诱导n -杂环氮催化α-氯酯单电子还原合成菲咯啶。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-24 DOI:10.1039/D5OB00530B

Ling Zhou, Xiao-Xue Pei, Wei Gong, He Sheng and Zhu-Sheng Yang

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引用次数: 0

摘要

可见光光氧化还原催化通过在温和条件下实现可持续的自由基介导转化，彻底改变了合成方法。本文报道了一种利用n -杂环氮（NHN）碘化盐驱动α-氯酯光还原的催化方案，生成与2-异氰酸双芳基环化的烷基自由基，用于模块化合成菲咯啉衍生物。这种方法的特点是易于获得nhn和操作简单。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photoinduced N-heterocyclic nitrenium-catalyzed single electron reduction of α-chloro esters for phenanthridine synthesis†

Visible-light photoredox catalysis has revolutionized synthetic methodologies by enabling sustainable radical-mediated transformations under mild conditions. Herein, we report a catalytic protocol employing N-heterocyclic nitrenium (NHN) iodide salts to drive the photoreduction of α-chloro esters, generating alkyl radicals that participate in annulation with 2-isocyanobiaryls for the modular synthesis of phenanthridine derivatives. This approach is characterized by easily available NHNs and operational simplicity.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.