马来西亚卫生填埋场渗滤液中的药物残留物和化学品:健康和环境危害的非目标分析和记录。

IF 5.8 3区 环境科学与生态学 0 ENVIRONMENTAL SCIENCES
Binaya Sapkota, Agamutu Pariatamby
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引用次数: 0

摘要

虽然垃圾填埋场在处理药物废物方面没有直接作用,但在垃圾渗滤液中仍检测到药物残留物(PRs)和药物化学物质(PCs)。然而,由于它们大量的代谢物和复杂的相互作用,它们在渗滤液样品中的详细探索仍然具有挑战性。本研究旨在对马来西亚卫生填埋场渗滤液中的pr和pc进行非目标分析。从2023年7月至2023年10月,在马来西亚雪兰莪州的Jeram卫生垃圾填埋场对总共28个样本进行了横断面研究。在渗滤液收集池附近的硼硅酸盐玻璃瓶中收集新鲜未经处理的渗滤液。用LCMS-QTOF系统对离心后的上清液进行分析。根据质量数据分析色谱谱图,并用METLIN数据库对化合物进行标注。共检出pr和PCs 7125例,其中pr 1288例(平均±SD 46.00±35.70),PCs 5837例(平均±SD 208.46±102.38)。健康危害1862例(25.6%),环境危害212例(3.0%)。同样,渗滤液中含有各种pc,可造成2417例(33.7%)健康危害,312例(4.4%)环境危害。这些健康危害是由毒性、超敏性、神经毒性、致癌性等多种机制引起的。同样,环境危害是由生态毒性、持久性和生物放大介导的。结果显示了渗滤液中pr和化学物质的可怕情景。这意味着必须在废物分类和人员处置以及卫生保健设施方面采取紧急干预措施,以限制未经事先稳定的药品和化学品进入非危险废物填埋场。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmaceutical residues and chemicals in landfill leachate from a sanitary landfill in Malaysia: non-target analysis and records of health and environmental hazards.

Pharmaceutical residues (PRs) and pharmaceutical chemicals (PCs) have been detected in landfill leachate though landfill sites have no direct role in managing pharmaceutical wastes. However, their detailed exploration is still challenging in leachate samples due to their vast array of metabolites and complex interactions. The present study is aimed to perform a non-target analysis of PRs and PCs in leachate from a sanitary landfill in Malaysia. Cross-sectional study of total 28 samples was conducted at Jeram Sanitary Landfill at Selangor, Malaysia, from July 2023 to October 2023. Grab sample of fresh untreated leachate was collected in a borosilicate glass bottle near leachate collection pond. The centrifuged supernatant liquid was analyzed with LCMS-QTOF system. The chromatographic profiles were analyzed based on mass data, and the compounds were annotated using METLIN database. A total of 7125 PRs and PCs were detected, out of which 1,288 were PRs (mean ± SD 46.00 ± 35.70) and 5837 were PCs (mean ± SD 208.46 ± 102.38). There were 1862 (25.6%) cases of health hazards, and 212 (3.0%) cases of environmental hazards caused by various PRs. Similarly, leachate was laden with various PCs that could cause 2417 (33.7%) cases of health hazards, and 312 (4.4%) cases of environmental hazards. These health hazards were caused by various mechanisms such as toxicity, hypersensitivity, neurotoxicity, carcinogenicity and other. Similarly, environmental hazards were mediated by ecotoxicity, persistence and biomagnification. The results showed the dire scenario of PRs and chemicals in leachate. This implies that urgent interventions be instituted in waste segregation and disposal of people and healthcare facilities to restrict entry of pharmaceutical products and chemicals into non-hazardous waste landfill without prior stabilization.

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来源期刊
CiteScore
8.70
自引率
17.20%
发文量
6549
审稿时长
3.8 months
期刊介绍: Environmental Science and Pollution Research (ESPR) serves the international community in all areas of Environmental Science and related subjects with emphasis on chemical compounds. This includes: - Terrestrial Biology and Ecology - Aquatic Biology and Ecology - Atmospheric Chemistry - Environmental Microbiology/Biobased Energy Sources - Phytoremediation and Ecosystem Restoration - Environmental Analyses and Monitoring - Assessment of Risks and Interactions of Pollutants in the Environment - Conservation Biology and Sustainable Agriculture - Impact of Chemicals/Pollutants on Human and Animal Health It reports from a broad interdisciplinary outlook.
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