Tagatose 1,6-bisphosphate aldolases, the unloved DHAP-aldolases.

Tagatose-1,6-bisphosphate aldolases (TagA) have been understudied. The limited publications on the subject report a poor stereoselectivity, which quickly led to their classification among the less interesting aldolases. This conclusion, which appeared inadequate, discouraged further investigation by other researchers. The objective here is to re-examine all these studies in detail to finally uncover inconsistencies and unexplained observations regarding the behaviour of these enzymes. Ultimately, there is a significant lack of research that could deepen our understanding of TagA, which would likely reveal its potential to be as valuable as its counterparts: fructose-1,6-bisphosphate, rhamnulose-1-phosphate, and fuculose-1-phosphate aldolases.