银催化α-亚胺氧酸生成酰基自由基：获得酰基化的3- cf3 -2-氧吲哚。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-29 DOI:10.1039/D5OB00262A

Yating Cao, Yushan Wei, Yingxin Hu, Daosheng Liu, Mengyao Liu, Jingjing Wang, Chong Li, Pinpin Wang, Liyan Hu and Feng Li

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引用次数: 0

摘要

本文报道了一种统一的策略，通过选择性的C-C键激活从α-亚胺-羧酸产生酰基自由基。在银催化剂的作用下，α-亚胺氧基酸可以进行脱羧和N-O键和C-C键的均裂以传递酰基自由基，随后被n -烷基- n -芳基-2-（三氟甲基）丙烯酰胺捕获以获得酰化的3- cf3 -2-氧吲哚。

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Silver-catalyzed generation of acyl radicals from α-imino-oxy acids: access to acylated 3-CF3-2-oxindoles†

A unified strategy to generate acyl radicals from α-imino-oxy acids via selective C–C bond activation is reported. In the presence of a silver catalyst, α-imino-oxy acids could undergo decarboxylation and N–O and C–C bond homolysis to deliver the acyl radicals, which were subsequently captured by N-alkyl-N-aryl-2-(trifluoromethyl)acrylamides to access acylated 3-CF₃-2-oxindoles.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.