加速向功能性糖蛋白组学迈进。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-05-09 DOI:10.1016/j.tibs.2025.04.002

Tim S Veth, Nicholas M Riley

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引用次数: 0

摘要

糖蛋白组的异质性以及在复杂生物系统中量化其调控的挑战阻碍了功能糖蛋白组学的发展。与现有方法相比，Potel、Burtscher和Garrido-Rodriguez等人最近开发的深度定量糖谱分析（DQGlyco）方法显著提高了糖蛋白组学深度，有助于我们探究糖蛋白的功能含义。

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Accelerating the stride toward functional glycoproteomics.

The heterogeneity of the glycoproteome and the challenges associated with quantifying its regulation in complex biological systems have hindered functional glycoproteomics. The deep quantitative glycoprofiling (DQGlyco) method recently developed by Potel, Burtscher, and Garrido-Rodriguez et al. significantly improves the glycoproteomic depth compared with existing methods, aiding our ability to interrogate the functional implications of glycoproteins.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.