α -gal综合征：识别和管理蜱叮咬相关的肉类过敏。

IF 3.4 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Cleveland Clinic Journal of Medicine Pub Date : 2025-05-01 DOI:10.3949/ccjm.92a.24072

Zehra Naseem, Aun Muhammad, Arjun Chatterjee, Alberto Rubio-Tapia

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引用次数: 0

摘要

α -半乳糖综合征是一种新出现的疾病，其特征是在食用哺乳动物来源的食品后，免疫球蛋白（Ig） e介导对半乳糖- α -1,3-半乳糖（α -半乳糖）的反应。该综合征在21世纪初被发现，与蜱虫叮咬致敏有关；在美国，孤星蜱（Amblyomma americanum）是主要的媒介。症状范围从瘙痒和荨麻疹到严重的全身反应，如过敏反应，通常发生在吃肉后3至8小时。诊断需要有一致的症状史、阳性α -半乳糖IgE血清学和饮食排除试验。管理的重点是避免食用含有α -gal的食物和产品，并防止蜱虫叮咬。

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Alpha-gal syndrome: Recognizing and managing a tick-bite-related meat allergy.

Alpha-gal syndrome is an emerging condition characterized by an immunoglobulin (Ig) E-mediated reaction to galactose-alpha-1,3-galactose (alpha-gal) after consumption of mammalian-derived food products. Identified in the early 2000s, the syndrome is linked to sensitization through tick bites; in the United States, the lone star tick (Amblyomma americanum) is the main vector. Symptoms range from pruritus and hives to severe systemic reactions like anaphylaxis, and typically occur 3 to 8 hours after eating meat. Diagnosis involves a history of consistent symptoms, positive alpha-gal IgE serology, and dietary exclusion trials. Management focuses on avoiding foods and products that contain alpha-gal and preventing tick bites.

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来源期刊

Cleveland Clinic Journal of Medicine 医学-医学：内科

CiteScore

3.80

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The mission of Cleveland Clinic Journal of Medicine (CCJM) is to provide its readers with up-to-date, practical, clinical information relevant to internal medicine, cardiology, and related fields. Consistent with this mission, CCJM focuses on timely review articles and other content that has a continuing-education orientation rather than on original research or case reports. CCJM authors, drawn from Cleveland Clinic and other top medical institutions throughout the world, are asked to identify new findings that are changing the practice of medicine and to advise readers how to apply them in daily patient care. Authors are chosen for their experience, acquired through caring for patients, teaching other physicians, and researching clinical questions.