用selectflut直接C-H氟化/氧吲哚与喹诺沙林-2(1H)- 1的异芳基化。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-30 DOI:10.1039/D5OB00427F

Hui Qin, Guo-Liang Wei, Wen-Geng Xie, Xiao-Hong Mao, Fu-Wei Wang, Mei-Hua Bao, Xiao-Wei Zheng, Yi-Wen Zhang and Ping Huang

{"title":"用selectflut直接C-H氟化/氧吲哚与喹诺沙林-2(1H)- 1的异芳基化。","authors":"Hui Qin, Guo-Liang Wei, Wen-Geng Xie, Xiao-Hong Mao, Fu-Wei Wang, Mei-Hua Bao, Xiao-Wei Zheng, Yi-Wen Zhang and Ping Huang","doi":"10.1039/D5OB00427F","DOIUrl":null,"url":null,"abstract":"Herein, we present an efficient and feasible strategy for direct C–H fluorination and heteroarylation of oxindoles on the C-3 position having a C(sp3)–H bond with quinoxalin-2(1H)-ones based on a radical coupling reaction via Selectfluor, a bifunctional reagent, as both the oxidant and fluorine source. This methodology provides a potential protocol to obtain 3-heteroaryl 3-fluorooxindoles in medium to excellent yields.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" 22","pages":" 5390-5395"},"PeriodicalIF":2.9000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Direct C–H fluorination/heteroarylation of oxindoles with quinoxalin-2(1H)-ones using Selectfluor†\",\"authors\":\"Hui Qin, Guo-Liang Wei, Wen-Geng Xie, Xiao-Hong Mao, Fu-Wei Wang, Mei-Hua Bao, Xiao-Wei Zheng, Yi-Wen Zhang and Ping Huang\",\"doi\":\"10.1039/D5OB00427F\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Herein, we present an efficient and feasible strategy for direct C–H fluorination and heteroarylation of oxindoles on the C-3 position having a C(sp3)–H bond with quinoxalin-2(1H)-ones based on a radical coupling reaction via Selectfluor, a bifunctional reagent, as both the oxidant and fluorine source. This methodology provides a potential protocol to obtain 3-heteroaryl 3-fluorooxindoles in medium to excellent yields.\",\"PeriodicalId\":96,\"journal\":{\"name\":\"Organic & Biomolecular Chemistry\",\"volume\":\" 22\",\"pages\":\" 5390-5395\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic & Biomolecular Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob00427f\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob00427f","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

本研究通过双功能试剂Selectfluor作为氧化剂和氟源，对具有C(sp3)-H键的喹啉-2(1H)-化合物进行自由基偶联反应，提出了一种高效可行的C-3位氧吲哚进行直接C-H氟化和杂芳化的策略。该方法提供了一种以中等至优异收率获得3-杂芳基3-氟辛酮的潜在方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Direct C–H fluorination/heteroarylation of oxindoles with quinoxalin-2(1H)-ones using Selectfluor†

Herein, we present an efficient and feasible strategy for direct C–H fluorination and heteroarylation of oxindoles on the C-3 position having a C(sp³)–H bond with quinoxalin-2(1H)-ones based on a radical coupling reaction via Selectfluor, a bifunctional reagent, as both the oxidant and fluorine source. This methodology provides a potential protocol to obtain 3-heteroaryl 3-fluorooxindoles in medium to excellent yields.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.