荚膜红杆菌PG脂多糖作为toll样受体2和4激活的潜在阻断剂。

IF 2 4区生物学 Q4 CELL BIOLOGY

Acta Naturae Pub Date : 2025-01-01 DOI:10.32607/actanaturae.27555

S V Zubova, Ya V Radzyukevich, N I Kosyakova, I R Prokhorenko

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引用次数: 0

摘要

TLR2和TLR4在细菌感染的炎症反应中起着关键作用。我们研究了荚膜红杆菌PG脂多糖（LPS）对TLR2和TLR4激动剂大肠杆菌LPS、化脓性链球菌脂质胆酸（LTA）和Pam3CSK4（一种合成的细菌脂肽）在人全血细胞中促炎细胞因子合成的激活作用。研究表明，荚膜红杆菌PG LPS对TLR4和TLR2激动剂具有拮抗作用，可阻断细胞因子TNF-α、IL-6和IL-8的合成。提出了荚膜红杆菌PG LPS抑制作用的可能机制。荚膜红杆菌PG LPS可以作为抗革兰氏阴性和革兰氏阳性细菌药物的原型。

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Rhodobacter capsulatus PG Lipopolysaccharide As a Potential Blocker of Toll-like Receptor 2 and 4 Activation.

TLR2 and TLR4 play a key role in the development of an inflammation in response to a bacterial infection. We studied the effect of Rhodobacter capsulatus PG lipopolysaccharide (LPS) on proinflammatory cytokine synthesis activation by the TLR2 and TLR4 agonists E. coli LPS, Streptococcus pyogenes lipoteichoic acid (LTA), and Pam3CSK4 (a synthetic bacterial lipopeptide) in human whole blood cells. Rhodobacter capsulatus PG LPS was shown to exhibit antagonistic properties against the studied TLR4 and TLR2 agonists, blocking the synthesis of the cytokines TNF-α, IL-6, and IL-8. Possible mechanisms behind the suppressing effect of Rhodobacter capsulatus PG LPS are proposed. Rhodobacter capsulatus PG LPS can serve as a prototype for drugs against both gram-negative and gram-positive bacteria.

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来源期刊

Acta Naturae 农林科学-林学

CiteScore

3.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.