乳腺癌组织中CIRBP mRNA水平与HIF1α基因表达和微血管密度相关。

IF 1.6 Q2 MULTIDISCIPLINARY SCIENCES

BMC Research Notes Pub Date : 2025-05-04 DOI:10.1186/s13104-025-07265-5

Sajad Monjezi, Vahid Soleimani, Maryam Cheraghzadeh, Saeed Ghanbari, Maryam Adelipour

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引用次数: 0

摘要

目的：根据现有证据，冷诱导rna结合蛋白（CIRBP）似乎在增加缺氧诱导因子1- α (HIF1α) mRNA的稳定性中起作用。本研究旨在检测乳腺肿瘤组织中CIRBP和HIF1α mRNA的表达水平，并探讨其基因表达与肿瘤微血管密度（MVD）的关系。结果：结果显示，与周围正常组织相比，BC样本中CIRBP（5.07倍）和HIF1α（4.5倍）基因表达显著上调(p

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CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density.

Objective: Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD).

Results: The results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC.

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来源期刊

BMC Research Notes Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

3.60

自引率

0.00%

发文量

363

审稿时长

15 weeks

期刊介绍： BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.