Minghua Sun, Fei Li, Xiaoyan Zhang, Rui Wu, Wenya Liu, Li Xu, Mengjie Wu, Yangang Wang
{"title":"表观扩散系数值在前列腺PI-RADS v2.1第1类“结节中的结节”鉴别良恶性病变中的诊断价值","authors":"Minghua Sun, Fei Li, Xiaoyan Zhang, Rui Wu, Wenya Liu, Li Xu, Mengjie Wu, Yangang Wang","doi":"10.1007/s00261-025-04930-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To explore the associations between the apparent diffusion coefficient (ADC) values of prostate PI-RADS v2.1 category 1 \"nodules in nodule\" and their pathological characteristics.</p><p><strong>Methods: </strong>We retrospectively analyzed the prostate images from 226 male patients who underwent biopsy following MRI from January 2019 to December 2024. Two radiologists evaluated the PI-RADS v2.1 categories of identified nodules, measured the ADC values of the prostate nodules in a double-blind manner, and analyzed the associations between these values and the pathological characteristics of the nodules via independent sample t tests or Mann-Whitney U test.</p><p><strong>Results: </strong>The ADC values of PI-RADS v2.1 category 1 \"nodules in nodule\" pathologically confirmed as clinically significant prostate cancer (csPCa) were lower than those of benign prostate hyperplasia (BPH) ((unit in ×10<sup>- 3</sup> mm<sup>2</sup>/s)TZ: 0.739 ± 0.15 versus 0.984 ± 0.24; PZ: 0.719 ± 0.17 versus 1.036 ± 0.21, p < 0.001). The AUCs were 0.799 (TZ) with a cutoff of 0.835 × 10<sup>- 3</sup>mm<sup>2</sup>/s, and 0.873(PZ) with a cutoff of 0.795 × 10<sup>- 3</sup>mm<sup>2</sup>/s, respectively. The total prostate-specific antigen (tPSA), free/t PSA, PSA density (PSAD), and prostate gland volume (PGV) differed significantly between patients with PI-RADS v2.1 \"nodules in nodule\" that were pathologically confirmed as csPCa and patients with BPH (all p < 0.05).</p><p><strong>Conclusion: </strong>In patients with PI-RADS v2.1 category 1 \"nodules in nodule\", when the ADC values are less than 0.835 × 10<sup>- 3</sup>mm<sup>2</sup>/s in the TZ, the PI-RADS v2.1 score of the nodule can be upgraded to 3.</p>","PeriodicalId":7126,"journal":{"name":"Abdominal Radiology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 \\\"nodules in nodule\\\".\",\"authors\":\"Minghua Sun, Fei Li, Xiaoyan Zhang, Rui Wu, Wenya Liu, Li Xu, Mengjie Wu, Yangang Wang\",\"doi\":\"10.1007/s00261-025-04930-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To explore the associations between the apparent diffusion coefficient (ADC) values of prostate PI-RADS v2.1 category 1 \\\"nodules in nodule\\\" and their pathological characteristics.</p><p><strong>Methods: </strong>We retrospectively analyzed the prostate images from 226 male patients who underwent biopsy following MRI from January 2019 to December 2024. Two radiologists evaluated the PI-RADS v2.1 categories of identified nodules, measured the ADC values of the prostate nodules in a double-blind manner, and analyzed the associations between these values and the pathological characteristics of the nodules via independent sample t tests or Mann-Whitney U test.</p><p><strong>Results: </strong>The ADC values of PI-RADS v2.1 category 1 \\\"nodules in nodule\\\" pathologically confirmed as clinically significant prostate cancer (csPCa) were lower than those of benign prostate hyperplasia (BPH) ((unit in ×10<sup>- 3</sup> mm<sup>2</sup>/s)TZ: 0.739 ± 0.15 versus 0.984 ± 0.24; PZ: 0.719 ± 0.17 versus 1.036 ± 0.21, p < 0.001). The AUCs were 0.799 (TZ) with a cutoff of 0.835 × 10<sup>- 3</sup>mm<sup>2</sup>/s, and 0.873(PZ) with a cutoff of 0.795 × 10<sup>- 3</sup>mm<sup>2</sup>/s, respectively. The total prostate-specific antigen (tPSA), free/t PSA, PSA density (PSAD), and prostate gland volume (PGV) differed significantly between patients with PI-RADS v2.1 \\\"nodules in nodule\\\" that were pathologically confirmed as csPCa and patients with BPH (all p < 0.05).</p><p><strong>Conclusion: </strong>In patients with PI-RADS v2.1 category 1 \\\"nodules in nodule\\\", when the ADC values are less than 0.835 × 10<sup>- 3</sup>mm<sup>2</sup>/s in the TZ, the PI-RADS v2.1 score of the nodule can be upgraded to 3.</p>\",\"PeriodicalId\":7126,\"journal\":{\"name\":\"Abdominal Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Abdominal Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00261-025-04930-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Abdominal Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00261-025-04930-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 "nodules in nodule".
Objectives: To explore the associations between the apparent diffusion coefficient (ADC) values of prostate PI-RADS v2.1 category 1 "nodules in nodule" and their pathological characteristics.
Methods: We retrospectively analyzed the prostate images from 226 male patients who underwent biopsy following MRI from January 2019 to December 2024. Two radiologists evaluated the PI-RADS v2.1 categories of identified nodules, measured the ADC values of the prostate nodules in a double-blind manner, and analyzed the associations between these values and the pathological characteristics of the nodules via independent sample t tests or Mann-Whitney U test.
Results: The ADC values of PI-RADS v2.1 category 1 "nodules in nodule" pathologically confirmed as clinically significant prostate cancer (csPCa) were lower than those of benign prostate hyperplasia (BPH) ((unit in ×10- 3 mm2/s)TZ: 0.739 ± 0.15 versus 0.984 ± 0.24; PZ: 0.719 ± 0.17 versus 1.036 ± 0.21, p < 0.001). The AUCs were 0.799 (TZ) with a cutoff of 0.835 × 10- 3mm2/s, and 0.873(PZ) with a cutoff of 0.795 × 10- 3mm2/s, respectively. The total prostate-specific antigen (tPSA), free/t PSA, PSA density (PSAD), and prostate gland volume (PGV) differed significantly between patients with PI-RADS v2.1 "nodules in nodule" that were pathologically confirmed as csPCa and patients with BPH (all p < 0.05).
Conclusion: In patients with PI-RADS v2.1 category 1 "nodules in nodule", when the ADC values are less than 0.835 × 10- 3mm2/s in the TZ, the PI-RADS v2.1 score of the nodule can be upgraded to 3.
期刊介绍：
Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section.
Reasons to Publish Your Article in Abdominal Radiology:
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European Society of Gastrointestinal and Abdominal Radiology (ESGAR)
European Society of Urogenital Radiology (ESUR)
Asian Society of Abdominal Radiology (ASAR)
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