TyG指数在糖脂代谢相关饮食模式与T2DM之间的中介作用:倾向评分匹配分析

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
ShuShu Li, Rong Xia, Xing Gong, Chao Wang, Hechun Liu, Huibin Dong, Zhangyao Su, Yucheng Liang, Shoulin Wang, Tao Yang
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引用次数: 0

摘要

目的:本研究旨在探讨饮食模式(DPs)与T2DM风险的关系,强调HOMA或TyG指数在中国成年人群中的中介作用。研究设计与方法:采用有向无环图结合倾向评分匹配,最大限度地减少混杂,最终纳入1330名受试者进行分析。主成分分析和降秩回归,应用于11个食品组。采用多变量logistic回归和限制三次样条回归模型来评估糖尿病患者的血压与T2DM、胰岛素抵抗和β细胞功能(HOMA-TyG)之间的关系。进行中介分析以评估HOMA-TyG指数是否介导了DPs和T2DM之间的关系。结果:以大量摄入家禽、肉类和腌制食品为特征的DP1与体重指数、甘油三酯和血红蛋白A1c升高有关。PCA-DP1(ORQ4VsQ1 = 2.15, 95% CI: 1.53-3.03)和RRR-DP1 (ORQ4VsQ1 = 1.69, 95% CI: 1.82-3.58)与T2DM呈显著正相关。另外,RRR-DP1与homa -胰岛素抵抗和TyG呈剂量依赖性关系。此外,TyG指数介导了RRR-DP1与T2DM之间约19.51%的关系。结论:这些研究结果表明,糖脂代谢相关的饮食模式,特别是高动物脂肪,会加剧胰岛素抵抗,增加2型糖尿病的风险。调整饮食干预来改变这种模式可能是预防和管理2型糖尿病的有效策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mediating effect of TyG index on the association between glucose-lipid metabolism-related dietary pattern and T2DM: a propensity score-matched analysis.

Objective: This study aimed to investigate the association of dietary patterns (DPs) with risk of T2DM, emphasizing the intermediary role of HOMA or TyG indices among a Chinese adult population.

Research design and methods: Directed acyclic graphs combined with propensity score matching were used to minimize confounding, resulting in 1330 subjects for final analysis. Principal component analysis and reduced rank regression, applied to eleven food groups. Multivariable logistic regression and restricted cubic spline regression models were used to assess associations between there DPs with prevalent T2DM, as well as insulin resistance and β-cell function (HOMA-TyG). Mediation analyses were conducted to evaluate whether the HOMA-TyG index mediated the relationship between DPs and T2DM.

Results: The DP1, characterized by high intakes of poultry, meat, and preserved foods, was associated with elevated body mass index, triglycerides, and hemoglobin A1c. Both PCA-DP1(ORQ4VsQ1 = 2.15, 95% CI: 1.53-3.03) and RRR-DP1 (ORQ4VsQ1 = 1.69, 95% CI: 1.82-3.58) were significantly positively correlated with T2DM. RRR-DP1 additionally demonstrated a dose-dependent relationship with HOMA-insulin resistance and TyG. Furthermore, the TyG index mediated approximately 19.51% of the relationship between RRR-DP1 and T2DM.

Conclusions: These findings indicate that glucose-lipid metabolism-related dietary pattern, notably high in animal fat, exacerbates insulin resistance and heightens T2DM risk. Tailoring dietary interventions to modify this pattern may be an effective strategy for preventing and managing T2DM.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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