丝胶蛋白诱导的雏鸡下咽通过M1毒蕈碱、NMDA、谷氨酸和甘氨酸受体介导。

Q3 Veterinary
Archives of Razi Institute Pub Date : 2024-10-31 eCollection Date: 2024-10-01 DOI:10.32592/ARI.2024.79.5.1109
N Movahedi, M Zendehdel, B Vazir, S Hassanpour
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引用次数: 0

摘要

本研究的目的是确定毒蕈碱、NMDA、谷氨酸和甘氨酸受体在丝胶蛋白诱导的雏鸡下食中的相互作用。本研究包括6个实验,每组4个,每组11次重复。在实验1中,鸡接受生理盐水、丝胶(0.5 nmol)或Telenzepine(一种M1毒蕈碱受体拮抗剂,125 nmol)的ICV注射。第4组联合注射丝胶蛋白和Telenzepine。实验2-6用AF-DX116 (M2型毒蕈碱受体拮抗剂,125 nmol)、4-DAMP (M3型毒蕈碱受体拮抗剂,125 nmol)、PD102807 (M4型毒蕈碱受体拮抗剂,125 nmol)、MK-801 (NMDA型谷氨酸受体拮抗剂,15 nmol)和士的宁(甘氨酸受体拮抗剂,100 nmol)代替Telenzepine进行ICV注射。随后,在注射后30min、60min和120min对累积进食量进行量化。结果表明,与对照组相比,ICV注射丝胶蛋白(0.5 nmol)可显著减少大鼠的累积摄食量(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sericin-Induced Hypophagia Mediates Via M1 Muscarinic, NMDA Glutamate and Glycine Receptors in Neonatal Chicken.

The objective of this study was to ascertain the interaction between muscarinic, NMDA glutamate, and glycine receptors on sericin-induced hypophagia in neonatal chickens. This study comprised six experiments, with four groups in each and 11 repeats per group. In Experiment 1, the chicken received an ICV injection of saline, sericin (0.5 nmol), or Telenzepine (an M1 muscarinic receptor antagonist, 125 nmol). Group 4 received a co-injection of sericin and Telenzepine. In experiments 2-6, the chicken received ICV injections of AF-DX116 (an M2 muscarinic receptor antagonist, 125 nmol), 4-DAMP (an M3 muscarinic receptor antagonist, 125 nmol), PD102807 (an M4 muscarinic receptor antagonist, 125 nmol), MK-801 (an NMDA glutamate receptor antagonist, 15 nmol), and strychnine (a glycine receptor antagonist, 100 nmol) instead of Telenzepine. Subsequently, the cumulative food intake was quantified at 30, 60, and 120 minutes post-injection. The results demonstrated that the ICV injection of sericin (0.5 nmol) led to a notable reduction in cumulative food intake when compared to the control group (P<0.05). The co-injection of telenzepine and sericin resulted in a notable reduction in the hypophagia induced by sericin, as evidenced by a statistically significant difference (P<0.05). The co-injection of MK-801 and sericin resulted in a reduction of the hypophagic effects of sericin when compared to the control group (P<0.05). The co-injection of strychnine and sericin resulted in a notable reduction in the hypophagic effects of sericin, as evidenced by a statistically significant difference when compared to the control group (P<0.05). These findings suggest that sericin-induced hypophagia is mediated via M1 muscarinic, NMDA glutamate, and glycine receptors in neonatal chickens.

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来源期刊
Archives of Razi Institute
Archives of Razi Institute Veterinary-Veterinary (all)
CiteScore
1.50
自引率
0.00%
发文量
108
审稿时长
12 weeks
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