基于光谱和化学分析的i型聚酮合成酶（PKS）衍生天然产物的构型分配：方法和案例研究。

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2025-04-23 DOI:10.1039/d4np00061g

Jinsheng Cui, Prima F Hillman, Geum Jin Kim, Thinh T M Bui, Kyuho Moon, Sang-Jip Nam, Hyukjae Choi, Dong-Chan Oh

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引用次数: 0

摘要

i型聚酮合成酶（PKS）衍生的代谢物是结构多样的生物活性天然产物，含有多个立体中心。本文综述了1型pks衍生的天然产物的构型分析，强调了由于其具有多个手性中心的复杂结构而确定其立体化学的方法和挑战。关键策略包括基于j的构型分析（JBCA）、手性试剂的化学衍生化、降解方法、核磁共振光谱分析和手性特性的开发。实例研究证明了这些方法在阐明i型聚酮天然产物立体化学中的实际应用。

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Configurational assignments of type-I polyketide synthase (PKS)-derived natural products based on spectroscopic and chemical analysis: methodologies and case studies.

Covering: 1992 to 2024Type-I polyketide synthase (PKS)-derived metabolites are structurally diverse bioactive natural products containing multiple stereogenic centres. This review focuses on the configurational analysis of type-I PKS-derived natural products, emphasizing the methodologies and challenges associated with determining their stereochemistry due to their complex structures with multiple chiral centres. Key strategies include J-based configuration analysis (JBCA), chemical derivatizations with chiral reagents, degradation methods, NMR spectroscopic analysis, and the exploitation of chiroptical properties. Case studies demonstrate the practical applications of these methods in elucidating the stereochemistry of type-I polyketide natural products.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.