ObMetrics:一个闪亮的应用程序,以协助代谢综合征评估在儿童肥胖。

IF 2.7 3区 医学 Q1 PEDIATRICS
Álvaro Torres-Martos, Francisco Requena, Guadalupe López-Rodríguez, Jhazmin Hernández-Cabrera, Marcos Galván, Elizabeth Solís-Pérez, Susana Romo-Tello, José Luis Jasso-Medrano, Jenny Vilchis-Gil, Miguel Klünder-Klünder, Gloria Martínez-Andrade, María Elena Acosta Enríquez, Juan Carlos Aristizabal, Alberto Ramírez-Mena, Nikos Stratakis, Mireia Bustos-Aibar, Ángel Gil, Mercedes Gil-Campos, Gloria Bueno, Rosaura Leis, Jesús Alcalá-Fdez, Concepción María Aguilera, Augusto Anguita-Ruiz
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引用次数: 0

摘要

目的:介绍一款免费且用户友好的Shiny应用程序ObMetrics,该应用程序可以根据儿科人群流行病学研究中的多种定义简化代谢综合征(MetS)结果的计算、数据分析和解释。我们使用不同种族的人群在跨队列和定义的患病率比较研究中说明了它的有用性。方法:我们使用来自两个不同种族的儿科人群的数据进行了一项病例研究:西班牙裔美国人队列(N = 1759)和西班牙裔欧洲人队列(N = 2411)。使用ObMetrics,我们计算met分类(Cook, Zimmet, Ahrens)和每个参与者特定组件的z分数来比较患病率。结果:分析显示MetS在不同定义和队列中的患病率存在显著的异质性。根据Cook、Zimmet和Ahrens的定义,肥胖儿童的met患病率在西班牙裔欧洲人群中分别为25%、12%和48%,在西班牙裔美国人群中分别为38%、27%和66%。在每个队列中计算组件特异性z分数也突出了脂质代谢和血压的种族特异性差异。通过自动化这些复杂的计算,ObMetrics大大减少了分析时间,并最大限度地减少了错误的可能性。结论:ObMetrics被证明是儿科研究的有力工具,根据各种定义和参考标准,生成关于MetS及其组成部分的详细报告。我们的案例研究进一步为描述儿科人群代谢健康的挑战提供了有价值的见解。未来的努力应侧重于制定统一共识的儿科MetS指南。同时,ObMetrics能够对高危儿童和青少年进行早期识别和有针对性的干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ObMetrics: A Shiny app to assist in metabolic syndrome assessment in paediatric obesity.

Objective: To introduce ObMetrics, a free and user-friendly Shiny app that simplifies the calculation, data analysis, and interpretation of Metabolic Syndrome (MetS) outcomes according to multiple definitions in epidemiological studies of paediatric populations. We illustrate its usefulness using ethnically different populations in a comparative study of prevalence across cohorts and definitions.

Methods: We conducted a case study using data from two ethnically diverse paediatric populations: a Hispanic-American cohort (N = 1759) and a Hispanic-European cohort (N = 2411). Using ObMetrics, we computed MetS classifications (Cook, Zimmet, Ahrens) and component-specific z-scores for each participant to compare prevalences.

Results: The analysis revealed significant heterogeneity in MetS prevalence across different definitions and cohorts. According to Cook, Zimmet, and Ahrens's definitions, MetS prevalence in children with obesity was 25%, 12%, and 48%, respectively, in the Hispanic-European cohort, and 38%, 27%, and 66% in the Hispanic-American cohort. Calculating component-specific z-scores in each cohort also highlighted ethnic-specific differences in lipid metabolism and blood pressure. By automating these complex calculations, ObMetrics considerably reduced analysis time and minimised the potential for errors.

Conclusion: ObMetrics proved to be a powerful tool for paediatric research, generating detailed reports on the prevalence of MetS and its components based on various definitions and reference standards. Our case study further provides valuable insights into the challenges of characterising metabolic health in paediatric populations. Future efforts should focus on developing unified consensus guidelines for paediatric MetS. Meanwhile, ObMetrics enables earlier identification and targeted intervention for high-risk children and adolescents.

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来源期刊
Pediatric Obesity
Pediatric Obesity PEDIATRICS-
CiteScore
7.30
自引率
5.30%
发文量
117
审稿时长
6-12 weeks
期刊介绍: Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.
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