底物和试剂依赖的脒和2-叔氨基苯甲醛的选择性环化。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-26 DOI:10.1039/d5ob00424a

Yi Zhang , Renchao Ma , Yongmin Ma , Weiwei Fang

引用次数: 0

摘要

在这里，我们提出了一种有效的和底物/试剂依赖的脒与2-叔氨基苯甲醛环化。当使用n -烷基苯并咪胺时，脒进行自环生成氢三嗪骨架。在相同的条件下，n -芳基苯并咪胺类化合物可制得喹唑啉类/对苯二酚类化合物。此外，在基本条件下，2-叔氨基苯甲醛与脒的偶联反应产生1,3,5-三嗪衍生物。

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Substrate- and reagent-dependent selective annulation of amidines and 2-tert-amino benzaldehydes†

Herein, we present an efficient and substrate/reagent-dependent annulation of amidines with 2-tert-amino benzaldehydes. When N-alkyl benzimidamides are employed, amidines undergo self-annulation to generate a hydrotriazine skeleton. In contrast, N-aryl benzimidamides yield quinazolines/hydroquinazolines under similar conditions. Additionally, the coupling of 2-tert-amino benzaldehydes with amidines under basic conditions yields 1,3,5-triazine derivatives.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.