甘油三酯-葡萄糖指数对炎症性肠病风险的影响

Q4 Medicine
Wang-Dong Fan, Wen-Qian Yu
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引用次数: 0

摘要

目的探讨甘油三酯-葡萄糖(TyG)指数对炎症性肠病(IBD)发病风险的影响。方法以英国生物银行(UK Biobank)数据为基础,根据TyG指数的位数分为TyG1(≤4.564)、TyG2(4.564-4.808)和TyG3(≥4.808)3组。建立Kaplan-Meier曲线分析IBD的累积发病率。进一步采用Cox比例风险回归分析各组的风险比(HR)及其95%可信区间(95% ci)。对IBD的不同亚型(溃疡性结肠炎和克罗恩病)进行了相同的分析。在排除一年内确诊的参与者后,基于竞争风险模型进行敏感性分析。结果共纳入116 423例受试者,中位随访时间为12.56年。TyG1、TyG2和TyG3组IBD发病率密度分别为4.47、5.94和6.50 / 10000人/年。IBD的累积发病率随着TyG的升高而升高,Log-rank检验结果显示组间累积发病率的差异(TyG2组和TyG3组IBD的PHR(95%CI)分别为1.50(1.21-1.85)和1.71(1.36-2.16)。调整混杂因素后的亚组分析结果显示,TyG3组溃疡性结肠炎和克罗恩病的HR(95%CI)分别为1.48(1.16-1.74)和2.27(1.51-3.42)。在排除了一年内确诊的参与者后,敏感分析得出了类似的结果。结论TyG指数越高,IBD及其亚型的发病风险越高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Triglyceride-Glucose Index on the Risk of Inflammatory Bowel Disease.

Objective To investigate the impact of the triglyceride-glucose(TyG)index on the risk of inflammatory bowel disease(IBD).Methods Based on the data from UK Biobank,participants were allocated into three groups,TyG1(≤4.564),TyG2(4.564-4.808),and TyG3(≥4.808),according to tertiles of the TyG index.Kaplan-Meier curves were established to analyze the cumulative incidence of IBD.Further,Cox proportional hazard regression was employed to analyze the hazard ratio(HR)and its 95% confidential interval(95%CI)of each group.The same analysis was conducted for different subtypes(ulcerative colitis and Crohn's disease)of IBD.Sensitive analysis based on the competing risk model was performed after excluding participants who were diagnosed within one year.Results A total of 116 423 participants were included in this study,with the median follow-up time of 12.56 years.The incidence densities of IBD in the TyG1,TyG2,and TyG3 groups were 4.47,5.94,and 6.50 per 10 000 person-year,respectively.The cumulative incidence of IBD increased with the rise in TyG,and Log-rank test results showed differences in cumulative incidence between groups(P<0.001).After adjusting the confounding factors,the HR(95%CI)of IBD in the TyG2 and TyG3 groups was 1.50(1.21-1.85)and 1.71(1.36-2.16),respectively.The results of the subgroup analysis after adjusting the confounding factors revealed that the HR(95%CI)of ulcerative colitis and Crohn's disease in the TyG3 group was 1.48(1.16-1.74)and 2.27(1.51-3.42),respectively.The sensitive analysis yielded similar results after excluding participants who were diagnosed within one year.Conclusion A high TyG index indicates an increased risk of IBD and its subtypes.

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来源期刊
中国医学科学院学报
中国医学科学院学报 Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
6813
期刊介绍: Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].
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