方便一步从四烷中构建熔融或两性离子茚。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-16 DOI:10.1039/d5ob00370a

Chencheng Liu , Yao Tong , Fenhua Wang , Qinghai Li

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引用次数: 0

摘要

本文开发了一种简单的方法，通过不同功能化的四烷与亲核试剂（乙烯基咔唑或DMSO）的一锅级联十六氢- diels - alder （HDDA）反应，构建融合或两性离子茚。该反应在温和的条件下进行，无金属催化剂、碱或氧化剂，具有优异的区域选择性和高收率。根据文献资料和分离的熔融茚酮，提出了两性离子茚酮的形成机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Convenient one-step construction of fused or zwitterionic indanes from tetraynes†

A straightforward technique has been developed for the construction of fused or zwitterionic indanes via a one-pot, cascade hexadehydro-Diels–Alder (HDDA) reaction of different functionalized tetraynes with nucleophilic reagents (vinyl carbazole or DMSO). The reaction proceeds under mild conditions with no metal catalysts, bases, or oxidants and exhibits excellent regioselectivity and high yields. A plausible reaction mechanism for the formation of zwitterionic indanes is proposed based on literatures and isolated fused indanes.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.