{"title":"肉桂利嗪与肉桂利嗪加苦杏仁油治疗耳鸣的疗效比较：一项随机对照试验。","authors":"Maryam Arabi, Assie Jokar, Mehdi Nikkhah, Seyed Nouraddin Mousavinasab, Zahra Memariani, Mojtaba Heydari, Seyed Hamdollah Mosavat","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Tinnitus is a common auditory disorder and is often associated with anxiety, depression, sleep disturbances, and irritability. The shortcomings of current treatment options justify the exploration of additional treatment methods. Otic delivery of bitter almond oil has been suggested in traditional Persian medicine as a remedy for tinnitus.</p><p><strong>Primary study objective: </strong>The study aimed to evaluate the efficacy and safety of bitter almond oil as an adjuvant in reducing the intensity of tinnitus.</p><p><strong>Methods/design: </strong>Randomized controlled trial comparing the effectiveness of cinnarizine versus cinnarizine plus otic bitter almond oil for tinnitus.</p><p><strong>Setting: </strong>The study was conducted at three medical centers, including Amir Alam Hospital, Imam Khomeini Hospital, and Baqiyatallah Hospital, affiliated with Mazandran University of Medical Sciences, Iran.</p><p><strong>Participants: </strong>Sixty-nine individuals who met the inclusion criteria (providing written consent, being between 18 and 75 years old, and being diagnosed with chronic tinnitus by an otorhinolaryngology specialist), were enrolled in the study and randomly assigned to two groups.</p><p><strong>Intervention: </strong>The intervention group received 2 drops of bitter almond oil into the ear and 25 mg of cinnarizine, while the control group received only 25 mg of cinnarizine twice daily for 4 weeks.</p><p><strong>Primary outcome measures: </strong>Changes in tinnitus intensity were evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and Visual Analogue Scale (VAS) at the end of the 4-week treatment period.</p><p><strong>Results: </strong>A significant difference was observed in total scores of VAS and THI after intervention in the experimental and control groups separately (P < .05). However, there were no significant differences in pre- and post-intervention scores for THI and VAS between the two groups (P > .05).</p><p><strong>Conclusion: </strong>The adjuvant use of bitter almond oil possibly helps to achieve a greater reduction in the intensity of tinnitus over time.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative Effectiveness of Cinnarizine Versus Cinnarizine Plus Otic Bitter Almond Oil for Tinnitus: A Randomized Controlled Trial.\",\"authors\":\"Maryam Arabi, Assie Jokar, Mehdi Nikkhah, Seyed Nouraddin Mousavinasab, Zahra Memariani, Mojtaba Heydari, Seyed Hamdollah Mosavat\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Tinnitus is a common auditory disorder and is often associated with anxiety, depression, sleep disturbances, and irritability. The shortcomings of current treatment options justify the exploration of additional treatment methods. Otic delivery of bitter almond oil has been suggested in traditional Persian medicine as a remedy for tinnitus.</p><p><strong>Primary study objective: </strong>The study aimed to evaluate the efficacy and safety of bitter almond oil as an adjuvant in reducing the intensity of tinnitus.</p><p><strong>Methods/design: </strong>Randomized controlled trial comparing the effectiveness of cinnarizine versus cinnarizine plus otic bitter almond oil for tinnitus.</p><p><strong>Setting: </strong>The study was conducted at three medical centers, including Amir Alam Hospital, Imam Khomeini Hospital, and Baqiyatallah Hospital, affiliated with Mazandran University of Medical Sciences, Iran.</p><p><strong>Participants: </strong>Sixty-nine individuals who met the inclusion criteria (providing written consent, being between 18 and 75 years old, and being diagnosed with chronic tinnitus by an otorhinolaryngology specialist), were enrolled in the study and randomly assigned to two groups.</p><p><strong>Intervention: </strong>The intervention group received 2 drops of bitter almond oil into the ear and 25 mg of cinnarizine, while the control group received only 25 mg of cinnarizine twice daily for 4 weeks.</p><p><strong>Primary outcome measures: </strong>Changes in tinnitus intensity were evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and Visual Analogue Scale (VAS) at the end of the 4-week treatment period.</p><p><strong>Results: </strong>A significant difference was observed in total scores of VAS and THI after intervention in the experimental and control groups separately (P < .05). However, there were no significant differences in pre- and post-intervention scores for THI and VAS between the two groups (P > .05).</p><p><strong>Conclusion: </strong>The adjuvant use of bitter almond oil possibly helps to achieve a greater reduction in the intensity of tinnitus over time.</p>\",\"PeriodicalId\":7571,\"journal\":{\"name\":\"Alternative therapies in health and medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alternative therapies in health and medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alternative therapies in health and medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Comparative Effectiveness of Cinnarizine Versus Cinnarizine Plus Otic Bitter Almond Oil for Tinnitus: A Randomized Controlled Trial.
Background: Tinnitus is a common auditory disorder and is often associated with anxiety, depression, sleep disturbances, and irritability. The shortcomings of current treatment options justify the exploration of additional treatment methods. Otic delivery of bitter almond oil has been suggested in traditional Persian medicine as a remedy for tinnitus.
Primary study objective: The study aimed to evaluate the efficacy and safety of bitter almond oil as an adjuvant in reducing the intensity of tinnitus.
Methods/design: Randomized controlled trial comparing the effectiveness of cinnarizine versus cinnarizine plus otic bitter almond oil for tinnitus.
Setting: The study was conducted at three medical centers, including Amir Alam Hospital, Imam Khomeini Hospital, and Baqiyatallah Hospital, affiliated with Mazandran University of Medical Sciences, Iran.
Participants: Sixty-nine individuals who met the inclusion criteria (providing written consent, being between 18 and 75 years old, and being diagnosed with chronic tinnitus by an otorhinolaryngology specialist), were enrolled in the study and randomly assigned to two groups.
Intervention: The intervention group received 2 drops of bitter almond oil into the ear and 25 mg of cinnarizine, while the control group received only 25 mg of cinnarizine twice daily for 4 weeks.
Primary outcome measures: Changes in tinnitus intensity were evaluated using the Tinnitus Handicap Inventory (THI) questionnaire and Visual Analogue Scale (VAS) at the end of the 4-week treatment period.
Results: A significant difference was observed in total scores of VAS and THI after intervention in the experimental and control groups separately (P < .05). However, there were no significant differences in pre- and post-intervention scores for THI and VAS between the two groups (P > .05).
Conclusion: The adjuvant use of bitter almond oil possibly helps to achieve a greater reduction in the intensity of tinnitus over time.
期刊介绍：
Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
