新型叠氮都乐化合物作为磷酸二酯酶4B抑制剂治疗免疫炎性疾病或紊乱。

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-04-07 eCollection Date: 2025-05-08 DOI:10.1021/acsmedchemlett.5c00158

Zhendong Song, Steven H Liang

引用次数: 0

摘要

该应用程序揭示了一系列新的叠氮哚化合物被鉴定为磷酸二酯酶4B （PDE4B）抑制剂。公开了化学合成、对PDE4B的酶抑制活性、对PDE4D的选择性和药物组合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Novel Azaindole Compounds as Phosphodiesterase 4B Inhibitors for Treating Immune-Inflammatory Diseases or Disorders.

This application reveals a novel series of azaindole compounds identified as phosphodiesterase 4B (PDE4B) inhibitors. The chemical synthesis, enzymatic inhibitory activity against PDE4B, selectivity over PDE4D, and pharmaceutical compositions are disclosed.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.