用于伤口敷料和术后抗粘连的具有湿组织黏附性能的坚固Janus水凝胶。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2025-05-19 Epub Date: 2025-04-13 DOI:10.1021/acsabm.5c00118
Yutong Wang, Weidong Gu, Kunyan Sui
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引用次数: 0

摘要

尽管近年来粘接剂水凝胶发展迅速,但传统的双面粘接剂在实现对湿组织的有效粘连和防止术后组织粘连方面仍面临挑战。在本研究中,通过精确调节水凝胶两个表面的游离羟基和酚羟基的分布,成功地设计了一种新型Janus水凝胶湿粘合剂。所得的Janus水凝胶在其上下表面表现出明显不同的粘合和非粘合性能。具体而言,通过简单的硼酸(BA)溶液浸泡工艺,BA与聚乙烯醇(PVA)和单宁酸(TA)交联,有效抑制羟基在上表面的暴露,导致低附着力。相比之下,下表面对各种湿组织保持着很强的附着力,即使在水下也是如此。猪皮黏附模拟验证了水凝胶底面对湿组织的强附着力,而低附着力的上表面有效地阻止了组织的粘附。此外,细胞相容性、溶血和凝血试验表明,PVA/TA/BA水凝胶具有良好的生物相容性和显著的止血性能。这种简单高效的制备策略为开发新型Janus水凝胶提供了可行的途径,为其在湿组织修复和术后抗粘连治疗中的应用奠定了坚实的理论和实践基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Robust Janus Hydrogel with Wet-Tissue Adhesive Properties for Wound Dressing and Anti-Postoperative Adhesion.

Although adhesive hydrogels have advanced rapidly in recent years, conventional double-sided adhesives still face challenges in achieving effective adhesion to wet tissues and preventing postoperative tissue adhesion. In this study, a novel Janus hydrogel wet adhesive was successfully designed by precisely regulating the distribution of free hydroxyl and phenolic hydroxyl groups on the two surfaces of the hydrogel. The resulting Janus hydrogel exhibits significantly different adhesive and nonadhesive properties on its upper and lower surfaces. Specifically, through a simple boric acid (BA) solution immersion process, BA cross-linked with poly(vinyl alcohol) (PVA) and tannic acid (TA), effectively suppressing the exposure of hydroxyl groups on the upper surface, leading to low adhesion. In contrast, the lower surface retains strong adhesion to various wet tissues, even underwater. Adhesion simulations with pig skin validated the robust adhesion of the hydrogel's bottom surface to wet tissues, while the low-adhesion upper surface effectively prevented tissue adhesion. Furthermore, cytocompatibility, hemolysis, and coagulation tests demonstrated that the PVA/TA/BA hydrogel possesses excellent biocompatibility and notable hemostatic properties. This simple and efficient preparation strategy offers a practical approach for developing novel Janus hydrogels, laying a solid theoretical and practical foundation for their application in wet tissue repair and postoperative antiadhesion treatments.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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