{"title":"用于伤口敷料和术后抗粘连的具有湿组织黏附性能的坚固Janus水凝胶。","authors":"Yutong Wang, Weidong Gu, Kunyan Sui","doi":"10.1021/acsabm.5c00118","DOIUrl":null,"url":null,"abstract":"<p><p>Although adhesive hydrogels have advanced rapidly in recent years, conventional double-sided adhesives still face challenges in achieving effective adhesion to wet tissues and preventing postoperative tissue adhesion. In this study, a novel Janus hydrogel wet adhesive was successfully designed by precisely regulating the distribution of free hydroxyl and phenolic hydroxyl groups on the two surfaces of the hydrogel. The resulting Janus hydrogel exhibits significantly different adhesive and nonadhesive properties on its upper and lower surfaces. Specifically, through a simple boric acid (BA) solution immersion process, BA cross-linked with poly(vinyl alcohol) (PVA) and tannic acid (TA), effectively suppressing the exposure of hydroxyl groups on the upper surface, leading to low adhesion. In contrast, the lower surface retains strong adhesion to various wet tissues, even underwater. Adhesion simulations with pig skin validated the robust adhesion of the hydrogel's bottom surface to wet tissues, while the low-adhesion upper surface effectively prevented tissue adhesion. Furthermore, cytocompatibility, hemolysis, and coagulation tests demonstrated that the PVA/TA/BA hydrogel possesses excellent biocompatibility and notable hemostatic properties. This simple and efficient preparation strategy offers a practical approach for developing novel Janus hydrogels, laying a solid theoretical and practical foundation for their application in wet tissue repair and postoperative antiadhesion treatments.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"3932-3940"},"PeriodicalIF":4.6000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Robust Janus Hydrogel with Wet-Tissue Adhesive Properties for Wound Dressing and Anti-Postoperative Adhesion.\",\"authors\":\"Yutong Wang, Weidong Gu, Kunyan Sui\",\"doi\":\"10.1021/acsabm.5c00118\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Although adhesive hydrogels have advanced rapidly in recent years, conventional double-sided adhesives still face challenges in achieving effective adhesion to wet tissues and preventing postoperative tissue adhesion. In this study, a novel Janus hydrogel wet adhesive was successfully designed by precisely regulating the distribution of free hydroxyl and phenolic hydroxyl groups on the two surfaces of the hydrogel. The resulting Janus hydrogel exhibits significantly different adhesive and nonadhesive properties on its upper and lower surfaces. Specifically, through a simple boric acid (BA) solution immersion process, BA cross-linked with poly(vinyl alcohol) (PVA) and tannic acid (TA), effectively suppressing the exposure of hydroxyl groups on the upper surface, leading to low adhesion. In contrast, the lower surface retains strong adhesion to various wet tissues, even underwater. Adhesion simulations with pig skin validated the robust adhesion of the hydrogel's bottom surface to wet tissues, while the low-adhesion upper surface effectively prevented tissue adhesion. Furthermore, cytocompatibility, hemolysis, and coagulation tests demonstrated that the PVA/TA/BA hydrogel possesses excellent biocompatibility and notable hemostatic properties. This simple and efficient preparation strategy offers a practical approach for developing novel Janus hydrogels, laying a solid theoretical and practical foundation for their application in wet tissue repair and postoperative antiadhesion treatments.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":\" \",\"pages\":\"3932-3940\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1021/acsabm.5c00118\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Robust Janus Hydrogel with Wet-Tissue Adhesive Properties for Wound Dressing and Anti-Postoperative Adhesion.
Although adhesive hydrogels have advanced rapidly in recent years, conventional double-sided adhesives still face challenges in achieving effective adhesion to wet tissues and preventing postoperative tissue adhesion. In this study, a novel Janus hydrogel wet adhesive was successfully designed by precisely regulating the distribution of free hydroxyl and phenolic hydroxyl groups on the two surfaces of the hydrogel. The resulting Janus hydrogel exhibits significantly different adhesive and nonadhesive properties on its upper and lower surfaces. Specifically, through a simple boric acid (BA) solution immersion process, BA cross-linked with poly(vinyl alcohol) (PVA) and tannic acid (TA), effectively suppressing the exposure of hydroxyl groups on the upper surface, leading to low adhesion. In contrast, the lower surface retains strong adhesion to various wet tissues, even underwater. Adhesion simulations with pig skin validated the robust adhesion of the hydrogel's bottom surface to wet tissues, while the low-adhesion upper surface effectively prevented tissue adhesion. Furthermore, cytocompatibility, hemolysis, and coagulation tests demonstrated that the PVA/TA/BA hydrogel possesses excellent biocompatibility and notable hemostatic properties. This simple and efficient preparation strategy offers a practical approach for developing novel Janus hydrogels, laying a solid theoretical and practical foundation for their application in wet tissue repair and postoperative antiadhesion treatments.
期刊介绍:
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.