铬（II）催化缩醛与α-三氟甲基烯烃的脱氟还原交偶联。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-07 DOI:10.1039/D5OB00547G

Zaiyang Li, Meiming Luo and Xiaoming Zeng

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引用次数: 0

摘要

本文报道了铬（II）催化缩醛与α-三氟甲基烯烃的脱氟还原交叉偶联反应。α-烷氧烷基自由基是由缩醛在催化铬和三甲基硅氯的协同作用下生成的。随后自由基与α-三氟甲基烯烃的选择性交叉偶联提供了一条在均烯丙基位置含有烷氧基取代基的gem-二氟烯烃的合成途径。

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Chromium(ii)-catalyzed defluorinative reductive cross-coupling of acetals with α-trifluoromethyl alkenes†

We report here the chromium(II)-catalyzed defluorinative reductive cross-coupling reaction of acetals with α-trifluoromethyl alkenes. α-Alkoxyalkyl radicals are generated from acetals under the synergistic effect of catalytic chromium and trimethylsilyl chloride. Subsequent selective cross-coupling of the radicals with α-trifluoromethyl alkenes provides a synthetic route to gem-difluoroalkenes that contain an alkoxy substituent at the homoallylic position.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.