{"title":"解码每分钟的GPCR相互作用组揭示激素信号的守门人","authors":"Wenqing Shui","doi":"10.1016/j.chembiol.2025.04.012","DOIUrl":null,"url":null,"abstract":"<div><div>In this issue of <em>Cell Chemical Biology</em>, Shchepinova et al.<span><span><sup>1</sup></span></span> map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal trafficking, enhancing our understanding of GPCR-mediated intracellular signaling and interactome dynamics.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 5","pages":"Pages 651-652"},"PeriodicalIF":7.2000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Decoding the minute-by-minute GPCR interactome unveils hormone signaling gatekeepers\",\"authors\":\"Wenqing Shui\",\"doi\":\"10.1016/j.chembiol.2025.04.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In this issue of <em>Cell Chemical Biology</em>, Shchepinova et al.<span><span><sup>1</sup></span></span> map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal trafficking, enhancing our understanding of GPCR-mediated intracellular signaling and interactome dynamics.</div></div>\",\"PeriodicalId\":265,\"journal\":{\"name\":\"Cell Chemical Biology\",\"volume\":\"32 5\",\"pages\":\"Pages 651-652\"},\"PeriodicalIF\":7.2000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Chemical Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451945625001357\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Chemical Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451945625001357","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Decoding the minute-by-minute GPCR interactome unveils hormone signaling gatekeepers
In this issue of Cell Chemical Biology, Shchepinova et al.1 map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal trafficking, enhancing our understanding of GPCR-mediated intracellular signaling and interactome dynamics.
Cell Chemical BiologyBiochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
14.70
自引率
2.30%
发文量
143
期刊介绍:
Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.