5岁以下儿童麻疹负担及其疫苗接种覆盖率的全球、区域和国家趋势:来自《2021年全球疾病负担研究》的最新系统分析

IF 4.8 2区 医学 Q1 INFECTIOUS DISEASES
Weiyang Chen , Min Du , Jie Deng , Min Liu , Jue Liu
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引用次数: 0

摘要

本研究调查了5岁以下儿童麻疹负担和含麻疹疫苗(MCV)覆盖率的趋势,重点关注COVID-19大流行的影响。方法:我们使用全球疾病负担2021数据和全球卫生数据交换中204个国家的MCV覆盖率,分析5岁以下儿童的麻疹发病率、死亡率和残疾调整生命年(DALYs)。通过估算全球、区域和国家层面的年百分比变化(EAPC),评估了1990年至2021年的趋势。结果2021年,麻疹在全球5岁以下儿童中造成410万例病例、4.81万例死亡和420万例伤残调整年。从1990年到2021年,发病率、死亡率和DALYs下降了90%以上,但社会人口指数低的地区仍然承担着最高的负担。在2019-2021年2019冠状病毒病大流行期间,全球麻疹负担总体下降,但东亚地区的死亡率(EAPC = 155.55, 95%可信区间[CI]: 53.89-324.38)和DALY率(EAPC = 146.94, 95% CI: 46.25-316.94)上升。大流行还扰乱了疫苗接种,MCV1的覆盖率下降(EAPC = - 2.08, 95% CI: - 3.30至- 0.85),逆转了68个国家(33.33%)和50个国家(24.51%)MCV1和MCV2的先前趋势。结论近30年来,全球麻疹发病率呈下降趋势,但地区差异依然存在。COVID-19大流行扰乱了疫苗接种工作,增加了儿童中爆发疫情的风险。加强努力对实现消除麻疹至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global, regional, and national trends of measles burden and its vaccination coverage among children under 5 years old: An updated systematic analysis from the Global Burden of Disease Study 2021

Objectives

This study examines trends in measles burden and measles-containing vaccine (MCV) coverage among children under 5 years old, with a focus on the impact of the COVID-19 pandemic.

Methods

We analyzed measles incidence, mortality, and disability-adjusted life years (DALYs) in children under 5 years old using Global Burden of Disease 2021 data and MCV coverage in 204 countries from the Global Health Data Exchange. Trends from 1990 to 2021 were assessed through estimated annual percentage change (EAPC) at global, regional, and national levels.

Results

In 2021, measles caused 4.1 million cases, 48.1 thousand deaths, and 4.2 million DALYs among children under 5 years old globally. From 1990 to 2021, incidence, mortality, and DALYs declined by over 90%, but low socio-demographic index regions continued to bear the highest burden. During the COVID-19 pandemic (2019-2021), the global measles burden declined overall, but mortality (EAPC = 155.55, 95% confidence interval [CI]: 53.89-324.38) and DALY rates (EAPC = 146.94, 95% CI: 46.25-316.94) in East Asia increased. The pandemic also disrupted vaccination, with MCV1 coverage declining (EAPC = −2.08, 95% CI: −3.30 to −0.85), reversing previous trends in 68 countries (33.33%) for MCV1 and 50 countries (24.51%) for MCV2.

Conclusion

Global measles incidence has declined over the past 30 years, but regional disparities persist. The COVID-19 pandemic disrupted vaccination efforts, raising the risk of outbreaks among children. Enhanced efforts are critical to achieving measles elimination.
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来源期刊
CiteScore
18.90
自引率
2.40%
发文量
1020
审稿时长
30 days
期刊介绍: International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.
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