Ming Hou, Yuanrui Wang, Hefei Yang, Jiajun Zhang, Prof. Dr. Xiao-Feng Wu
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Photo-Promoted Nitrogen-Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β-Amino Ketones through (Hetero)Aryl Migration
Carbon monoxide, as a crucial C1 synthon, has been widely used in the difunctionalization of alkenes. Additionally, nitrogen-centered radicals (NCRs) are also effective intermediates for constructing C−N bonds. Herein, a nitrogen-centered radical-mediated aminative carbonylation strategy for producing β-amino ketones from tertiary allyl alcohols has been disclosed. Good yields of β-amino ketones with different functional groups were generated effectively under light irradiation.
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