橙皮苷对实验性糖尿病血脂、炎症和细胞凋亡的影响

IF 0.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kenan Yıldızhan, Mehmet Hafit Bayir, Zübeyir Huyut, Fikret Altındağ
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引用次数: 0

摘要

近年来,针对糖尿病性肝损伤的治疗方法引起了人们的极大兴趣。研究表明柑橘类水果中的类黄酮橙皮苷(HESP)具有抗癌、抗炎、抗氧化和降脂的潜力。本研究探讨HESP如何预防链脲佐菌素(STZ)诱导的糖尿病肝损害。造4组大鼠,每组7只:对照组、HESP (100 mg/kg/d)、STZ (45 mg/kg)和STZ + HESP(分别为45 mg/kg和100 mg/kg/d)。STZ组血清AST、ALT、LDH、LDL、甘油三酯、总胆固醇水平及肝组织TNF-α、IL-1β、caspase-3表达水平均高于其他组(p <;0.05)。然而,这些值明显较低(p <;0.05),与STZ组比较,STZ + HESP组差异无统计学意义。此外,HESP联合STZ可降低肝脏caspase-3、TNF-α和IL-1β的表达水平,以及血液中AST、ALT、LDH、LDL、甘油三酯和总胆固醇的水平。HESP抗糖尿病引起的肝损伤可降低促炎细胞因子水平,使脂质谱和凋亡指标恢复到正常水平。这些发现提示HESP治疗可能对糖尿病引起的肝损伤具有重要的治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Hesperidin on Lipid Profile, Inflammation and Apoptosis in Experimental Diabetes

In recent years, therapeutic approaches against diabetes-induced liver damage have attracted great interest. Studies indicate the anticarcinogenic, anti-inflammatory, antioxidant, and lipid-lowering potential of hesperidin (HESP), a flavonoid in citrus fruits. This study examined how HESP prevented streptozotocin (STZ)-induced diabetic liver damage. Four groups of seven rats each were created: Control, HESP (100 mg/kg/day), STZ (45 mg/kg), and STZ + HESP (45 mg/kg and 100 mg/kg/day, respectively). Serum AST, ALT, LDH, LDL, triglyceride, total cholesterol levels, and the TNF-α, IL-1β, and caspase-3 expression levels of liver tissue in the STZ group were higher than the other groups (p < 0.05). However, these values were significantly lower (p < 0.05) in the STZ + HESP group compared to the STZ group. Furthermore, administering HESP together with STZ reduced liver expression levels of caspase-3, TNF-α, and IL-1β, as well as blood levels of AST, ALT, LDH, LDL, triglyceride, and total cholesterol. HESP against diabetes-induced hepatic damage reduced proinflammatory cytokine levels, and returned the lipid profile, and apoptotic indicators to normal levels. These findings suggested that HESP therapy may be an important therapeutic role against diabetes-induced liver damage.

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来源期刊
Doklady Biochemistry and Biophysics
Doklady Biochemistry and Biophysics 生物-生化与分子生物学
CiteScore
1.60
自引率
12.50%
发文量
68
审稿时长
6-12 weeks
期刊介绍: Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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