ag促进α-酮酸与末端炔自由基脱羧环构吲哚酮

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-11 DOI:10.1016/j.tetlet.2025.155648

Hong Dai , Lei Luo , Luo Yang

引用次数: 0

摘要

通过自由基脱羧、加成和环化级联，实现了ag促进α-酮酸与末端炔的自由基脱羧环化，得到C2苯甲酰茚酮。末端炔直接作为底物，具有良好的rego选择性。第二个苯甲酰自由基被安装在茚酮的C2上，有利于潜在的后功能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ag-promoted radical decarboxylative annulation of α-keto acids with terminal alkynes to construct Indenones

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Ag-promoted radical decarboxylative annulation of α-keto acids with terminal alkynes to construct Indenones

An Ag-promoted radical decarboxylative annulation of α-keto acids with terminal alkynes to provide C2 benzoylated indenones is realized, via radical decarboxylation, addition and cyclization cascade. Terminal alkynes were used directly as the substrate with excellent reigo-selectivity. The second benzoyl radical was installed onto the C2 of indeonone, benefiting the potential post-functionalization.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.