高尔基复合体中PI4P的调控和功能

IF 3.9 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular and cell biology of lipids Pub Date : 2025-05-09 DOI:10.1016/j.bbalip.2025.159626

Maria Antonietta De Matteis , Marianna Fico , Rossella Venditti

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引用次数: 0

摘要

在Bob michel富有远见的预测五十年后，磷脂酰肌醇4-磷酸（PI4P）已成为高尔基体功能的中心调节因子，影响膜运输、脂质代谢和信号传导。PI4P的稳态受到磷脂酰肌醇4-激酶（PI4Ks）、磷脂酰肌醇转移蛋白（PITPs）和磷酸酶SAC1的严格控制，确保了高尔基子结构域的精确调控。除了在囊泡运输中的经典作用外，PI4P还协调膜接触部位的脂质交换，使动态高尔基体成熟和功能特化成为可能。PI4P、脂质转移蛋白和高尔基接合体之间的相互作用是货物分选、糖基化和细胞器结构的基础。新出现的证据也强调了PI4P在肿瘤发生和细胞信号传导中的作用，将高尔基体定位为除分泌外的关键中枢。然而，关于PI4P区隔化及其更广泛的生理影响的关键问题仍然存在。这篇综述回顾了PI4P的基本功能，将历史的见解与最近的发现结合起来，阐明了它在高尔基体生物学和其他领域的关键作用。

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Regulation and function of PI4P at the Golgi complex

Fifty years after Bob Michell's visionary prediction, phosphatidylinositol 4-phosphate (PI4P) has emerged as a central regulator of Golgi function, influencing membrane trafficking, lipid metabolism, and signaling. PI4P homeostasis is tightly controlled by phosphatidylinositol 4-kinases (PI4Ks), phosphatidylinositol transfer proteins (PITPs), and the phosphatase SAC1, ensuring precise regulation across Golgi subdomains. Beyond its classical role in vesicular transport, PI4P orchestrates lipid exchange at membrane contact sites, enabling dynamic Golgi maturation and functional specialization. The interplay between PI4P, lipid transfer proteins, and Golgi adaptors underlies cargo sorting, glycosylation, and organelle architecture. Emerging evidence also highlights PI4P's role in oncogenesis and cellular signaling, positioning the Golgi as a critical hub beyond secretion. Yet, key questions remain regarding PI4P compartmentalization and its broader physiological impact. This review revisits PI4P's essential functions, integrating historical insights with recent discoveries to illuminate its pivotal role in Golgi biology and beyond.

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来源期刊

Biochimica et biophysica acta. Molecular and cell biology of lipids 生物-生化与分子生物学

CiteScore

11.00

自引率

2.10%

发文量

109

审稿时长

53 days

期刊介绍： BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.