兼职蛋白在神经发生中的作用

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-05-15 DOI:10.1016/j.conb.2025.103047

Florencia Merino , Magdalena Götz

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引用次数: 0

摘要

哺乳动物大脑的复杂性一定来自相对较少的基因。具有兼职功能的蛋白质，即在不同的区室或细胞类型中具有完全不同的功能，有助于增加功能多样性。在这里，我们回顾了这些在神经发生和神经元成熟过程中具有兼职功能的蛋白质的例子。这些范围从作为转录调节剂的细胞骨架蛋白或结合并调节细胞骨架的突触蛋白或外显子连接蛋白到调节内质网脂质代谢的即时早期基因转录因子。我们进一步讨论了具有这种兼职功能的蛋白质如何促进细胞器的异质性，从而形成大脑中细胞类型的多样性。

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The role of moonlighting proteins in neurogenesis

The complexity of the mammalian brain must arise from a comparably small number of genes. Proteins with moonlighting functions, i.e. entirely different functions in different compartments or cell types, contribute to multiply functional diversity. Here we review examples of such proteins with moonlighting functions during neurogenesis and in neuronal maturation. These range from cytoskeletal proteins acting as transcriptional regulators or synaptic proteins or exon junction proteins binding to and regulating the cytoskeleton to immediate early gene transcription factors regulating lipid metabolism in the endoplasmic reticulum. We further discuss how proteins with such moonlighting functions contribute to the heterogeneity of organelles shaping cell-type diversity in the brain.

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience