日本人群下颌前突易感基因的全基因组分析

IF 2.6 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Biosciences Pub Date : 2025-05-09 DOI:10.1016/j.job.2025.100670

Marie Hoshi-Numahata , Atsuko Nakanishi-Kimura , Haruhisa Watanabe , Mai Nishiura , Shinnosuke Nishimoto , Fumi Ueno , Riyu Koguchi , Akira Oka , Yoshiaki Sato , Takashi S. Kajii , Tadahiro Iimura

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引用次数: 0

摘要

背景：下颌前突症（MP）是一种以上下颌骨前后位置不平衡为特征的错颌畸形。MP在日本的患病率相对较高，表明在人群中有独特的遗传背景。亮点：全基因组分析确定了日本人群下颌前伸症的易感基因。结论错颌畸形相关基因的鉴定将为个性化、精准化治疗铺平道路，并有助于颅面生物学的研究。

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Genome-wide analyses of susceptibility genes responsible for mandibular prognathism in the Japanese population

Background

Mandibular prognathism (MP) is a type of malocclusion characterized by an imbalance in the anteroposterior position of the upper and lower jaws. The prevalence of MP in Japan is relatively high, suggesting a unique genetic background in the population.

Highlight

Genome-wide analyses identified susceptibility genes responsible for mandibular prognathism in the Japanese population.

Conclusion

Identification of the genes associated with malocclusion will pave the way for personalized and precise medicine and contribute to craniofacial biology.

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来源期刊

Journal of Oral Biosciences DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.40

自引率

12.50%

发文量

审稿时长

37 days