光诱导PhI(OAc)2介导的醛的交叉脱氢异芳基化

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-14 DOI:10.1021/acs.joc.5c00655

Lusina Mantry, Parthasarathy Gandeepan

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引用次数: 0

摘要

通过光诱导高价碘介导的交叉脱氢偶联反应，建立了杂芳烃与醛的直接酰化反应。该反应通过酰基C-H氢原子转移（HAT）从醛原位生成亲核酰基自由基，然后与杂芳烃发生迷你型反应。实验证明，所建立的反应体系适用于多种杂环和醛类化合物的交叉偶联反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photoinduced PhI(OAc)2-Mediated Cross-Dehydrogenative Heteroarylation of Aldehydes

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Photoinduced PhI(OAc)2-Mediated Cross-Dehydrogenative Heteroarylation of Aldehydes

Direct acylation of heteroarenes with aldehydes has been established through a photoinduced hypervalent iodine-mediated cross-dehydrogenative coupling reaction. The reaction proceeds through the in situ generation of nucleophilic acyl radicals from aldehydes via acyl C–H hydrogen atom transfer (HAT), followed by a Minisci-type reaction with heteroarenes. The developed reaction system proved to be suitable for cross-coupling a diverse range of heterocycles and aldehydes.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.