在停滞微流体环境中设计增强混合:人工纤毛方法。

IF 5.4 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Lab on a Chip Pub Date : 2025-05-01 DOI:10.1039/D5LC00186B
Tongsheng Wang, Ishu Aggarwal, Erik Steur, Tess Homan, Patrick R. Onck, Jaap M. J. den Toonder and Ye Wang
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引用次数: 0

摘要

在停滞的微流体环境中混合对于许多应用来说是必不可少的,但由于难以在亚毫米尺度上产生有效的流动干扰,因此实现这一目标本身就具有挑战性。传统的无源微混频器需要外部驱动流才能工作,而有源混频器通常具有限制性用例和不良副作用。在这项研究中,我们设计了一个6 × 6阵列的多方向倾斜磁性人造纤毛,可以使用新开发的微成型工艺制造。该阵列可以通过产生由纤毛倾斜的锥形运动产生的重叠涡流来产生强烈的局部混合,也可以通过产生由预先设计的、交叉的净流矢量集合组成的复杂流型来产生有效的全局混合。实验结果表明,在频率为20 Hz的旋转磁场作用下,纤毛在25秒内可在静止微流体环境中有效混合。我们进行了完全耦合的模拟来设计纤毛的三维运动。对具有规定运动的双纤毛系统的模拟为设计大型阵列提供了参考,并对整个阵列进行了模拟,以分析三维混合效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Designing enhanced mixing in stagnant microfluidic environments: an artificial cilia approach†

Designing enhanced mixing in stagnant microfluidic environments: an artificial cilia approach†

Mixing in stagnant microfluidic environments is essential for many applications but is inherently challenging to achieve, due to the difficulty in generating effective flow disturbances at the sub-millimetre scale. Traditional passive micromixers require externally driven flow to work, while active mixers often have restrictive use cases with undesirable side-effects. In this study, we designed a 6 × 6 array of multi-directionally inclined magnetic artificial cilia that can be manufactured using a newly developed micromolding process. The array can generate strong local mixing by creating overlapping vortical flows generated by the cilia's tilted conical motion, as well as efficient global mixing by producing a complex flow pattern composed of a collection of predesigned, criss-crossing net flow vectors. Experimental results show effective mixing in stagnant microfluidic environments within 25 seconds when the cilia are actuated by a rotating global magnetic field at a frequency of 20 Hz. We performed fully coupled simulations to design the 3D motion of the cilia. Simulations of double-cilia systems with prescribed motion provide insights for designing the large array, and a simulation of the full array was performed to analyse the mixing effect in 3D.

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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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