铑催化芳香C-H烯丙基化与α，β-不饱和亚胺。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-13 DOI:10.1021/acs.joc.5c00484

Wei-Tao Hu,Zhong-Xia Wang

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引用次数: 0

摘要

在2.5 mol %的[Cp*RhCl2]2和10 mol %的AgSbF6存在下，2-芳基吡啶与α，β-不饱和亚胺在丙酮中反应得到烯丙基化的2-芳基吡啶，烯丙基段有一个烯胺单元。该方法具有邻位单烯丙基化选择性和C-C双键的z -选择性，适用于广泛的底物，与卤化物、CF3、coom、OH、MeO和酮基等空气和官能团兼容。

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Rhodium-Catalyzed Aromatic C-H Allylation with α,β-Unsaturated Imines.

Reaction of 2-arylpyridines with α,β-unsaturated imines in the presence of 2.5 mol % of [Cp*RhCl2]2 and 10 mol % of AgSbF6 in acetone affords allylated 2-arylpyridines with an enamine unit located in the allyl segment. This method features ortho-monoallylation selectivity and Z-selectivity of the C-C double bonds, is applicable to a wide range of substrates, and is compatible with air and functional groups such as halides, CF3, COOMe, OH, MeO, and ketal groups.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.