Atg9是溶酶体修复的保守调节因子。

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-05-13 DOI:10.1083/jcb.202504129

Ruoxi Wang,Eric H Baehrecke

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引用次数: 0

摘要

ATG9跨膜蛋白搅乱脂质以调节自噬过程中吞噬细胞的形成。Peng等人（https://doi.org/10.1083/jcb.202411092）和De Tito等人（https://doi.org/10.1101/2024.07.23.604321）最近的两项研究发现，ATG9是秀丽隐杆线虫和人类细胞中溶酶体修复的保守调节因子，但这些分类群之间的修复机制存在差异。

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Atg9 is a conserved regulator of lysosome repair.

The ATG9 transmembrane protein scrambles lipids to regulate phagophore formation during autophagy. Two recent studies from Peng et al. (https://doi.org/10.1083/jcb.202411092) and De Tito et al. (https://doi.org/10.1101/2024.07.23.604321) identify ATG9 as a conserved regulator of lysosome repair in Caenorhabditis elegans and human cells, but differences in repair mechanisms exist between these taxa.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.