疟疾疫苗接受的决定因素：意识、接受、犹豫和支付意愿的系统回顾和荟萃分析

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2025-05-14 DOI:10.1002/iid3.70205

Ganesh Bushi, Mahalaqua Nazli Khatib, Renuka Jyothi. S, Irwanjot Kaur, Abhishek Sharma, Suhaib Iqbal, M. Ravi Kumar, Ashish Singh Chauhan, Teena Vishwakarma, Praveen Malik, Quazi Syed Zahiruddin, Mahendra Pratap Singh, Muhammed Shabil, Rachana Mehta, Sanjit Sah, Hawra Albayat, Tarek Sulaiman, Ali Al bshabshe, Nawal A. Al Kaabi, Hayam A Alrasheed, Mubarak Alfaresi, Amal A. Sabour, Eman Alamri, Maha F. Al-Subaie, Ali A. Rabaan

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引用次数: 0

摘要

疟疾是一种由疟原虫引起的威胁生命的疾病，通过受感染的雌性按蚊叮咬传播。它仍然是一个重大的全球健康问题，2023年有2.63亿例病例和59.7万人死亡，主要影响幼儿和孕妇。本综述评估了RTS，S/AS01疟疾疫苗的认知、接受、犹豫和支付意愿（WTP），以及影响这些结果的关键因素。方法在Web of Science、PubMed和Embase数据库中检索到2024年6月18日的文献。包括评估疟疾流行地区对疟疾疫苗的认识、接受、犹豫和WTP的观察性研究。两名独立评审员对这些研究进行了筛选。使用Nested Knowledge软件进行数据提取，并使用R v.4.4进行分析。使用随机效应模型估计合并患病率，并使用I²统计量评估异质性。结果18项研究，21,975名参与者提供了对疟疾疫苗动态的见解：32%的意识（95% CI, 18%-50%）， 83%的接受（95% CI, 75%-89%）， 14%的犹豫（95% CI, 7%-26%）和58%的WTP （95% CI, 34%-79%）。接受度的关键决定因素包括年龄，其中年轻人（18-24岁）的接受度较低（OR = 0.64, 95% CI, 0.35-0.93）。就业，特别是农民，有更高的接受率（OR = 3.20, 95% CI, 1.00-7.40）。较低的社会经济地位和较大的家庭规模与较低的接受度相关（OR = 0.18, 95% CI, 0.02-0.38）。结论本综述显示疟疾疫苗的接受率为83%，存在认知度（32%）、犹豫（14%）和支付意愿（58%）的差异。年龄、就业和社会经济地位是接受与否的重要决定因素。然而，由于潜在的发表偏倚和高度异质性，这些发现应谨慎解释。这些结果强调了采取有针对性的干预措施以提高疫苗接受度的必要性。需要进一步的研究来阐明影响疫苗接受的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta-Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay

Background

Malaria is a life-threatening disease caused by Plasmodium parasites, transmitted through the bites of infected female Anopheles mosquitoes. It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant women. This review evaluates awareness, acceptance, hesitancy, and willingness to pay (WTP) for the RTS,S/AS01 malaria vaccine, along with the key factors influencing these outcomes.

Methods

A comprehensive literature search was conducted in Web of Science, PubMed, and Embase, covering publications up to 18 June 2024. Observational studies assessing awareness, acceptance, hesitancy, and WTP for the malaria vaccine in endemic regions were included. Two independent reviewers screened the studies. Data extraction was performed using Nested Knowledge software and analyzed with R v.4.4. Pooled prevalences were estimated using random-effects models, and heterogeneity was assessed with the I² statistic.

Results

Eighteen studies with 21,975 participants provided insights into malaria vaccine dynamics: 32% awareness (95% CI, 18%–50%), 83% acceptance (95% CI, 75%–89%), 14% hesitancy (95% CI, 7%–26%), and 58% WTP (95% CI, 34%–79%). Key determinants of acceptance included age, where younger adults (18–24 years) showed lower acceptance (OR = 0.64, 95% CI, 0.35–0.93). Employment, particularly farmers, had higher acceptance rates (OR = 3.20, 95% CI, 1.00–7.40). Lower socioeconomic status and larger family sizes were associated with decreased acceptance (OR = 0.18, 95% CI, 0.02–0.38).

Conclusion

This review revealed an 83% acceptance rate for the malaria vaccine, with variability in awareness (32%), hesitancy (14%), and willingness to pay (58%). Age, employment, and socioeconomic status were significant determinants of acceptance. However, due to potential publication bias and high heterogeneity, these findings should be cautiously interpreted. The results highlight the necessity for targeted interventions to enhance vaccine acceptance. Further research is required to elucidate factors that influence vaccine acceptance.

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology