可见光催化n -芳基甘氨酸和亚甲基亚胺级联合成吡唑烷酮的研究

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-08 DOI:10.1039/d5ob00497g

Ganesh Udari , A. Jansi Rani , B. Sridhar , Surya Prakash Singh

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引用次数: 0

摘要

我们提出了一种有效的可见光驱动方法，以N-芳基甘氨酸和亚甲基亚胺为原料合成N-（β-氨基）吡唑烷-3-酮。该无添加剂方案在室温下利用蓝光（λmax = 435-445 nm），实现自由基介导的级联反应，以高达99%的收率提供多种吡唑烷酮。该工艺条件温和，效率高，底物范围广，使其成为药物发现和材料科学中具有吸引力的流线型合成策略。

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Visible light-promoted cascade synthesis of pyrazolidinones via N-aryl glycine and azomethine imines†

We present an effective, visible light-driven method for the synthesis of N-(β-amino)pyrazolidin-3-ones from N-aryl glycine and azomethine imines. This additive-free protocol utilizes blue light (λ_max = 435–445 nm) at room temperature, enabling a radical-mediated cascade reaction that delivers a diverse range of pyrazolidinones in yields up to 99%. The mild conditions, high efficiency, and broad substrate scope of this process make it an attractive strategy for streamlined synthesis in drug discovery and material science.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.