用短tr绝热反转恢复（STAIR）序列量化髓磷脂和髓磷脂水的年龄相关变化

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2025-01-01 DOI:10.1016/j.nicl.2025.103801

James Lo , Jiaji Wang , Dylan Tran , Gabrielle Nemeh , Brandon Liu , Soo Hyun Shin , Jiyo S. Athertya , Dawn Schiehser , Yajun Ma , Jiang Du

{"title":"用短tr绝热反转恢复（STAIR）序列量化髓磷脂和髓磷脂水的年龄相关变化","authors":"James Lo , Jiaji Wang , Dylan Tran , Gabrielle Nemeh , Brandon Liu , Soo Hyun Shin , Jiyo S. Athertya , Dawn Schiehser , Yajun Ma , Jiang Du","doi":"10.1016/j.nicl.2025.103801","DOIUrl":null,"url":null,"abstract":"<div><div>Myelin proton density fraction (MPDF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of aging and neurodegeneration, but the effects of aging on MPDF/MWF remain unknown. This study aims to assess relationships between age and MPDF/MWF using the 3D STAIR ultrashort echo time (STAIR-UTE) and STAIR short echo time (STAIR-STE) sequences, respectively. 42 volunteers (29 young (<55y), 13 old (>55y)), were recruited for MPDF and MWF mapping for white matter (WM) and gray matter (GM) on a 3 T scanner. Excellent inter-reader reliability was demonstrated for MPDF and MWF measurements with ICC values of 0.97 and 0.98, respectively, between two readers. In the young group, WM MPDF and MWF range from 8-13 % and 6–13 %, respectively, while GM MPDF and MWF range from 5-7 % and 3–5 %, respectively. In the old group, WM MPDF and MWF range from 6-12 % and 5–13 %, and GM MPDF and MWF range from 3-6 % and 2–5 %, respectively. The young group’s MPDF/MWF values were significantly higher than those of the old group. Altogether, the 42 volunteers display linear and quadratic associations of MPDF/MWF with age. MPDF demonstrated significant correlations with MWF in the majority of brain regions. This study demonstrates the capability of two myelin imaging biomarkers, STAIR-UTE measured MPDF and STAIR-STE measured MWF to map brain myelin and MW. These biomarkers hold the potential to differentiate normal aging from neuroinflammatory/neurodegenerative diseases.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103801"},"PeriodicalIF":3.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-related changes in myelin and myelin water quantified with short-TR adiabatic inversion-recovery (STAIR) sequences\",\"authors\":\"James Lo , Jiaji Wang , Dylan Tran , Gabrielle Nemeh , Brandon Liu , Soo Hyun Shin , Jiyo S. Athertya , Dawn Schiehser , Yajun Ma , Jiang Du\",\"doi\":\"10.1016/j.nicl.2025.103801\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Myelin proton density fraction (MPDF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of aging and neurodegeneration, but the effects of aging on MPDF/MWF remain unknown. This study aims to assess relationships between age and MPDF/MWF using the 3D STAIR ultrashort echo time (STAIR-UTE) and STAIR short echo time (STAIR-STE) sequences, respectively. 42 volunteers (29 young (<55y), 13 old (>55y)), were recruited for MPDF and MWF mapping for white matter (WM) and gray matter (GM) on a 3 T scanner. Excellent inter-reader reliability was demonstrated for MPDF and MWF measurements with ICC values of 0.97 and 0.98, respectively, between two readers. In the young group, WM MPDF and MWF range from 8-13 % and 6–13 %, respectively, while GM MPDF and MWF range from 5-7 % and 3–5 %, respectively. In the old group, WM MPDF and MWF range from 6-12 % and 5–13 %, and GM MPDF and MWF range from 3-6 % and 2–5 %, respectively. The young group’s MPDF/MWF values were significantly higher than those of the old group. Altogether, the 42 volunteers display linear and quadratic associations of MPDF/MWF with age. MPDF demonstrated significant correlations with MWF in the majority of brain regions. This study demonstrates the capability of two myelin imaging biomarkers, STAIR-UTE measured MPDF and STAIR-STE measured MWF to map brain myelin and MW. These biomarkers hold the potential to differentiate normal aging from neuroinflammatory/neurodegenerative diseases.</div></div>\",\"PeriodicalId\":54359,\"journal\":{\"name\":\"Neuroimage-Clinical\",\"volume\":\"46 \",\"pages\":\"Article 103801\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimage-Clinical\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213158225000713\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROIMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimage-Clinical","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213158225000713","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROIMAGING","Score":null,"Total":0}

引用次数: 0

摘要

髓鞘质子密度分数（MPDF）和髓鞘水分数（MWF）是衰老和神经退行性变的潜在生物标志物，但衰老对MPDF/MWF的影响尚不清楚。本研究旨在分别利用三维STAIR超短回波时间（STAIR- ute）和STAIR短回波时间（STAIR- ste）序列评估年龄与MPDF/MWF之间的关系。招募了42名志愿者（29名年轻（55岁），13名年长（55岁）），在3t扫描仪上对白质（WM）和灰质（GM）进行MPDF和MWF制图。MPDF和MWF测量在两个阅读器之间的ICC值分别为0.97和0.98，显示出良好的阅读器间可靠性。在年轻组中，WM MPDF和MWF分别在8- 13%和6 - 13%之间，而GM MPDF和MWF分别在5- 7%和3 - 5%之间。在老年组中，WM MPDF和MWF分别为6- 12%和5 - 13%，GM MPDF和MWF分别为3- 6%和2 - 5%。年轻组MPDF/MWF值显著高于老年组。总的来说，42名志愿者的MPDF/MWF与年龄呈线性和二次关系。在大多数脑区，MPDF与MWF表现出显著的相关性。这项研究证明了两种髓磷脂成像生物标志物，即STAIR-UTE测量的MPDF和STAIR-STE测量的MWF能够绘制脑髓磷脂和MW。这些生物标志物具有区分正常衰老与神经炎症/神经退行性疾病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Age-related changes in myelin and myelin water quantified with short-TR adiabatic inversion-recovery (STAIR) sequences

Myelin proton density fraction (MPDF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of aging and neurodegeneration, but the effects of aging on MPDF/MWF remain unknown. This study aims to assess relationships between age and MPDF/MWF using the 3D STAIR ultrashort echo time (STAIR-UTE) and STAIR short echo time (STAIR-STE) sequences, respectively. 42 volunteers (29 young (<55y), 13 old (>55y)), were recruited for MPDF and MWF mapping for white matter (WM) and gray matter (GM) on a 3 T scanner. Excellent inter-reader reliability was demonstrated for MPDF and MWF measurements with ICC values of 0.97 and 0.98, respectively, between two readers. In the young group, WM MPDF and MWF range from 8-13 % and 6–13 %, respectively, while GM MPDF and MWF range from 5-7 % and 3–5 %, respectively. In the old group, WM MPDF and MWF range from 6-12 % and 5–13 %, and GM MPDF and MWF range from 3-6 % and 2–5 %, respectively. The young group’s MPDF/MWF values were significantly higher than those of the old group. Altogether, the 42 volunteers display linear and quadratic associations of MPDF/MWF with age. MPDF demonstrated significant correlations with MWF in the majority of brain regions. This study demonstrates the capability of two myelin imaging biomarkers, STAIR-UTE measured MPDF and STAIR-STE measured MWF to map brain myelin and MW. These biomarkers hold the potential to differentiate normal aging from neuroinflammatory/neurodegenerative diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.