SERCA在血管疾病中的作用，一个潜在的治疗靶点

IF 4 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2025-05-07 DOI:10.1016/j.ceca.2025.103039

Qinghua Yu, Wen Tian

{"title":"SERCA在血管疾病中的作用，一个潜在的治疗靶点","authors":"Qinghua Yu, Wen Tian","doi":"10.1016/j.ceca.2025.103039","DOIUrl":null,"url":null,"abstract":"<div><div>SERCA, the sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase, is a pivotal protein that transports calcium ions (Ca<sup>2+</sup>) from the cytoplasm into the sarcoplasmic/endoplasmic reticulum (SR/ER), thus sustaining cellular Ca<sup>2+</sup> homeostasis. A growing body of evidence indicates that SERCA dysfunction correlates with disrupted cellular Ca<sup>2+</sup> homeostasis and ER stress, precipitating a spectrum of chronic diseases. As a regulator of Ca<sup>2+</sup> homeostasis, SERCA emerges as a potential therapeutic target for conditions associated with Ca<sup>2+</sup> imbalance. This review delineates the association between SERCA and a variety of vascular diseases.</div></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":"129 ","pages":"Article 103039"},"PeriodicalIF":4.0000,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of SERCA in vascular diseases, a potential therapeutic target\",\"authors\":\"Qinghua Yu, Wen Tian\",\"doi\":\"10.1016/j.ceca.2025.103039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>SERCA, the sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase, is a pivotal protein that transports calcium ions (Ca<sup>2+</sup>) from the cytoplasm into the sarcoplasmic/endoplasmic reticulum (SR/ER), thus sustaining cellular Ca<sup>2+</sup> homeostasis. A growing body of evidence indicates that SERCA dysfunction correlates with disrupted cellular Ca<sup>2+</sup> homeostasis and ER stress, precipitating a spectrum of chronic diseases. As a regulator of Ca<sup>2+</sup> homeostasis, SERCA emerges as a potential therapeutic target for conditions associated with Ca<sup>2+</sup> imbalance. This review delineates the association between SERCA and a variety of vascular diseases.</div></div>\",\"PeriodicalId\":9678,\"journal\":{\"name\":\"Cell calcium\",\"volume\":\"129 \",\"pages\":\"Article 103039\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell calcium\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S014341602500048X\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell calcium","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S014341602500048X","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

sarca，即肌浆/内质网Ca2+- atp酶，是将钙离子（Ca2+）从细胞质转运到肌浆/内质网（SR/ER），从而维持细胞Ca2+稳态的关键蛋白。越来越多的证据表明，SERCA功能障碍与细胞Ca2+稳态破坏和内质网应激相关，从而引发一系列慢性疾病。作为Ca2+稳态的调节因子，SERCA成为Ca2+失衡相关疾病的潜在治疗靶点。本文综述了SERCA与多种血管疾病之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The role of SERCA in vascular diseases, a potential therapeutic target

查看原文本刊更多论文

The role of SERCA in vascular diseases, a potential therapeutic target

SERCA, the sarco/endoplasmic reticulum Ca²⁺-ATPase, is a pivotal protein that transports calcium ions (Ca²⁺) from the cytoplasm into the sarcoplasmic/endoplasmic reticulum (SR/ER), thus sustaining cellular Ca²⁺ homeostasis. A growing body of evidence indicates that SERCA dysfunction correlates with disrupted cellular Ca²⁺ homeostasis and ER stress, precipitating a spectrum of chronic diseases. As a regulator of Ca²⁺ homeostasis, SERCA emerges as a potential therapeutic target for conditions associated with Ca²⁺ imbalance. This review delineates the association between SERCA and a variety of vascular diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes