聚吡咯修饰hfgf2油体抑制黑色素瘤术后复发和促进创面愈合

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-09 DOI:10.1016/j.colsurfb.2025.114771

Shuwei Nie , Manru Wang , Zixuan Wang , Hang Yu , Zhuoyuan Li , Zhiqi Yang , Hongxiang Liu , Zheng Liu , Hongxia Ma , Xin Liu , Rui Chen , Yan Cheng

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引用次数: 0

摘要

手术治疗是目前治疗恶性黑色素瘤的主要方法。然而，手术后肿瘤复发和伤口愈合困难仍然是重大挑战。本研究通过将聚吡咯（PPy）负载到人成纤维细胞生长因子2 （hFGF2）共价结合的亚麻荠油体（h-OB）中形成Ph-OB，设计并构建了一种治疗性伤口敷料。在C57BL/6小鼠术后B16F10黑色素瘤模型中，利用PPy的光热特性，通过近红外光照射，提高手术创面部位的温度，进行光热治疗，杀死残留肿瘤，抑制肿瘤复发。同时，Ph-OB中hFGF2的释放作用于术后创面部位，促进成纤维细胞增殖和迁移，加速创面愈合。综上所述，开发的Ph-OB不仅可以防止肿瘤复发，还可以促进手术伤口的愈合，在癌症术后治疗中具有很大的潜力。

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Polypyrrole modified hFGF2-oil bodies for postsurgical melanoma recurrence suppression and wound healing acceleration

Surgical treatment is the primary method for treating malignant melanoma at present. However, tumor recurrence after surgery and difficulty in wound healing remain significant challenges. This study designed and constructed a therapeutic wound dressing by loading polypyrrole (PPy) into human fibroblast growth factor 2 (hFGF2) covalently bonded camelina oil bodies (h-OB) to form Ph-OB. In a postoperative B16F10 melanoma model in C57BL/6 mice, the photothermal properties of PPy were utilized to increase the temperature at the surgical wound site through near-infrared light irradiation, performing photothermal therapy to kill residual tumors and inhibit tumor recurrence. Meanwhile, the release of hFGF2 from the Ph-OB acts on the postoperative wound site, promotes fibroblast proliferation and migration to accelerate wound healing. In summary, the developed Ph-OB not only prevents tumor recurrence but also facilitates the healing of surgery-induced wounds, showing great potential in postoperative cancer treatment.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.