恶唑- 3-氨基吡啶-2(1H)- 1杂环的高效合成

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-07 DOI:10.1016/j.tetlet.2025.155615

Yunge Yuan , Jiacheng Liu , Fangzhi Huang , Changqing Wei , Wei Zhang

引用次数: 0

摘要

3-氨基吡啶-2(1H)- 1衍生物因其生物活性而备受关注，而恶唑杂环化合物也是药物化学中重要的药效团。本文从市售材料出发，通过cu催化的分子内CN偶联，高效合成了恶唑-融合的3-氨基吡啶-2(1H)- 1。该方法具有广泛的衬底适应性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An efficient synthesis of oxazole-fused 3-Aminopyridin-2(1H)-one heterocycles

查看原文本刊更多论文

An efficient synthesis of oxazole-fused 3-Aminopyridin-2(1H)-one heterocycles

3-Aminopyridin-2(1H)-one derivatives are of high interest due to their biological activity, and oxazole-fused heterocyclic compounds are also important pharmacophore in medicinal chemistry. Starting from commercially available materials, this article presents an efficient synthesis of oxazole-fused 3-aminopyridin-2(1H)-one via CuI-catalyzed intramolecular CN coupling. This method has a wide range of substrate adaptability.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.