肿瘤相关中性粒细胞亚型及其在癌症免疫治疗中的作用

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2025-05-05 DOI:10.1016/j.critrevonc.2025.104763

Xinyun Chu , Ning Pu , Xue Yang , Yuqi Xie , Liang Liu , Yun Jin

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引用次数: 0

摘要

中性粒细胞是先天免疫系统的重要组成部分。肿瘤相关中性粒细胞（TANs）受肿瘤微环境（TME）的影响，导致其生物学特性和功能的显著异质性。单细胞测序的最新进展揭示了广泛的TAN亚型，但仍缺乏全面的分类系统。本综述旨在总结肿瘤免疫治疗后TAN亚组的变化，并确定促肿瘤和抗肿瘤亚组之间的区别和共同点。目前的临床前和临床研究进展也很突出，包括针对TANs的新疗法。

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Subtypes of tumor-associated neutrophils and their roles in cancer immunotherapy

Neutrophils are essential components of the innate immune system. Tumor-associated neutrophils (TANs) are shaped by tumor microenvironment (TME), leading to significant heterogeneity in biological characteristics and functions. Recent advances in single-cell sequencing have revealed a wide array of TAN subtypes, while a comprehensive classification system is still lacking. This review aims to summarize the alterations observed in TAN subgroups following cancer immunotherapy, and identify the distinctions and commonalities between pro-tumor and anti-tumor subgroups. Current progress of preclinical and clinical studies is also highlighted, involving novel therapies targeting TANs.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.