利用抗微生物药物耐药性机制、检测和策略方面的进展

IF 8.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2025-05-14 DOI:10.1016/j.scitotenv.2025.179641

Ritik Kumar Thakur , Kaushal Aggarwal , Nayan Sood , Aman Kumar , Sachin Joshi , Priya Jindal , Rashmi Maurya , Preeti Patel , Balak Das Kurmi

{"title":"利用抗微生物药物耐药性机制、检测和策略方面的进展","authors":"Ritik Kumar Thakur , Kaushal Aggarwal , Nayan Sood , Aman Kumar , Sachin Joshi , Priya Jindal , Rashmi Maurya , Preeti Patel , Balak Das Kurmi","doi":"10.1016/j.scitotenv.2025.179641","DOIUrl":null,"url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is a growing global health crisis, threatening the effectiveness of antibiotics and other antimicrobial agents, leading to increased morbidity, mortality, and economic burdens. This review article provides a comprehensive analysis of AMR, beginning with a timeline of antibiotics discovery and the year of first observed resistance. Main mechanisms of AMR in bacteria, fungi, viruses, and parasites are summarized, and the main mechanisms of bacteria are given in detail. Additionally, we discussed in detail methods for detecting AMR, including phenotypic, genotypic, and advanced methods, which are crucial for identifying and monitoring AMR. In addressing AMR mitigation, we explore innovative interventions such as CRISPR-Cas systems, nanotechnology, antibody therapy, artificial intelligence (AI), and the One Health approach. Moreover, we discussed both finished and ongoing clinical trials for AMR. This review emphasizes the urgent need for global action and highlights promising technologies that could shape the future of AMR surveillance and treatment. By integrating interdisciplinary research and emerging clinical insights, this study aims to guide individuals toward impactful solutions in the battle against AMR.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179641"},"PeriodicalIF":8.2000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Harnessing advances in mechanisms, detection, and strategies to combat antimicrobial resistance\",\"authors\":\"Ritik Kumar Thakur , Kaushal Aggarwal , Nayan Sood , Aman Kumar , Sachin Joshi , Priya Jindal , Rashmi Maurya , Preeti Patel , Balak Das Kurmi\",\"doi\":\"10.1016/j.scitotenv.2025.179641\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Antimicrobial resistance (AMR) is a growing global health crisis, threatening the effectiveness of antibiotics and other antimicrobial agents, leading to increased morbidity, mortality, and economic burdens. This review article provides a comprehensive analysis of AMR, beginning with a timeline of antibiotics discovery and the year of first observed resistance. Main mechanisms of AMR in bacteria, fungi, viruses, and parasites are summarized, and the main mechanisms of bacteria are given in detail. Additionally, we discussed in detail methods for detecting AMR, including phenotypic, genotypic, and advanced methods, which are crucial for identifying and monitoring AMR. In addressing AMR mitigation, we explore innovative interventions such as CRISPR-Cas systems, nanotechnology, antibody therapy, artificial intelligence (AI), and the One Health approach. Moreover, we discussed both finished and ongoing clinical trials for AMR. This review emphasizes the urgent need for global action and highlights promising technologies that could shape the future of AMR surveillance and treatment. By integrating interdisciplinary research and emerging clinical insights, this study aims to guide individuals toward impactful solutions in the battle against AMR.</div></div>\",\"PeriodicalId\":422,\"journal\":{\"name\":\"Science of the Total Environment\",\"volume\":\"982 \",\"pages\":\"Article 179641\"},\"PeriodicalIF\":8.2000,\"publicationDate\":\"2025-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science of the Total Environment\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0048969725012823\",\"RegionNum\":1,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science of the Total Environment","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0048969725012823","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

抗菌素耐药性（AMR）是一个日益严重的全球健康危机，威胁到抗生素和其他抗菌素药物的有效性，导致发病率、死亡率和经济负担增加。这篇综述文章提供了抗生素耐药性的全面分析，从抗生素发现的时间表和首次观察到耐药性的年份开始。综述了抗生素耐药性在细菌、真菌、病毒和寄生虫中的主要机制，并详细介绍了细菌的主要机制。此外，我们还详细讨论了AMR的检测方法，包括表型、基因型和先进的方法，这些方法对AMR的识别和监测至关重要。在缓解抗菌素耐药性方面，我们探索了创新的干预措施，如CRISPR-Cas系统、纳米技术、抗体治疗、人工智能（AI）和“同一个健康”方法。此外，我们还讨论了已完成和正在进行的抗菌素耐药性临床试验。这篇综述强调了迫切需要采取全球行动，并强调了可能影响未来抗菌素耐药性监测和治疗的有前途的技术。通过整合跨学科研究和新兴临床见解，本研究旨在指导个人在与AMR的斗争中找到有效的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Harnessing advances in mechanisms, detection, and strategies to combat antimicrobial resistance

Antimicrobial resistance (AMR) is a growing global health crisis, threatening the effectiveness of antibiotics and other antimicrobial agents, leading to increased morbidity, mortality, and economic burdens. This review article provides a comprehensive analysis of AMR, beginning with a timeline of antibiotics discovery and the year of first observed resistance. Main mechanisms of AMR in bacteria, fungi, viruses, and parasites are summarized, and the main mechanisms of bacteria are given in detail. Additionally, we discussed in detail methods for detecting AMR, including phenotypic, genotypic, and advanced methods, which are crucial for identifying and monitoring AMR. In addressing AMR mitigation, we explore innovative interventions such as CRISPR-Cas systems, nanotechnology, antibody therapy, artificial intelligence (AI), and the One Health approach. Moreover, we discussed both finished and ongoing clinical trials for AMR. This review emphasizes the urgent need for global action and highlights promising technologies that could shape the future of AMR surveillance and treatment. By integrating interdisciplinary research and emerging clinical insights, this study aims to guide individuals toward impactful solutions in the battle against AMR.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.