{"title":"超声触发纳米颗粒诱导铜增生以增强免疫原性声动力治疗","authors":"Jia Huang, Fuzhen Hu, Hanchen Zhang, Zheng Cao, Haihua Xiao, Zhiying Yang, Qionghua Jin, Kun Shang","doi":"10.1002/adma.202504228","DOIUrl":null,"url":null,"abstract":"Cuproptosis, as a novel mechanism of cell death, holds significant promise for tumor therapy. However, existing studies typically employ methods to induce cuproptosis through endogenous or exogenous pathways, which often fail to achieve precise control in both space and time. Herein, polymeric nanoparticles (RC NPs) are developed that enable precise activation of cuproptosis through acoustic control for tumor-specific treatment. The nanoparticles are fabricated via self-assembly of a degradable, acoustic-sensitive polymer (Poly RA) and a metal-ion-loadable polyphenol-structured polymer (Poly MPN). Ultrasound stimulation cleaved the RC NPs, generating reactive oxygen species (ROS) and promoting the release of copper ions from Poly MPN, leading to the aggregation of lipoylated proteins and depletion of iron-sulfur cluster proteins to introduce cuproptosis. Subsequently, the RC NPs successfully activated the immune system of mice, promoting the maturation of antigen-presenting cells and the activation of T lymphocytes. The nanoparticles exhibited good biosafety and significant tumor inhibition in both orthotopic and patient-derived xenograft (PDX) models. These novel nanoparticles provide a promising modality for the treatment of highly aggressive cancers and a valuable avenue for future clinical applications.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"123 1","pages":""},"PeriodicalIF":27.4000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultrasound-Triggered Nanoparticles Induce Cuproptosis for Enhancing Immunogenic Sonodynamic Therapy\",\"authors\":\"Jia Huang, Fuzhen Hu, Hanchen Zhang, Zheng Cao, Haihua Xiao, Zhiying Yang, Qionghua Jin, Kun Shang\",\"doi\":\"10.1002/adma.202504228\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cuproptosis, as a novel mechanism of cell death, holds significant promise for tumor therapy. However, existing studies typically employ methods to induce cuproptosis through endogenous or exogenous pathways, which often fail to achieve precise control in both space and time. Herein, polymeric nanoparticles (RC NPs) are developed that enable precise activation of cuproptosis through acoustic control for tumor-specific treatment. The nanoparticles are fabricated via self-assembly of a degradable, acoustic-sensitive polymer (Poly RA) and a metal-ion-loadable polyphenol-structured polymer (Poly MPN). Ultrasound stimulation cleaved the RC NPs, generating reactive oxygen species (ROS) and promoting the release of copper ions from Poly MPN, leading to the aggregation of lipoylated proteins and depletion of iron-sulfur cluster proteins to introduce cuproptosis. Subsequently, the RC NPs successfully activated the immune system of mice, promoting the maturation of antigen-presenting cells and the activation of T lymphocytes. The nanoparticles exhibited good biosafety and significant tumor inhibition in both orthotopic and patient-derived xenograft (PDX) models. These novel nanoparticles provide a promising modality for the treatment of highly aggressive cancers and a valuable avenue for future clinical applications.\",\"PeriodicalId\":114,\"journal\":{\"name\":\"Advanced Materials\",\"volume\":\"123 1\",\"pages\":\"\"},\"PeriodicalIF\":27.4000,\"publicationDate\":\"2025-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1002/adma.202504228\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adma.202504228","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Ultrasound-Triggered Nanoparticles Induce Cuproptosis for Enhancing Immunogenic Sonodynamic Therapy
Cuproptosis, as a novel mechanism of cell death, holds significant promise for tumor therapy. However, existing studies typically employ methods to induce cuproptosis through endogenous or exogenous pathways, which often fail to achieve precise control in both space and time. Herein, polymeric nanoparticles (RC NPs) are developed that enable precise activation of cuproptosis through acoustic control for tumor-specific treatment. The nanoparticles are fabricated via self-assembly of a degradable, acoustic-sensitive polymer (Poly RA) and a metal-ion-loadable polyphenol-structured polymer (Poly MPN). Ultrasound stimulation cleaved the RC NPs, generating reactive oxygen species (ROS) and promoting the release of copper ions from Poly MPN, leading to the aggregation of lipoylated proteins and depletion of iron-sulfur cluster proteins to introduce cuproptosis. Subsequently, the RC NPs successfully activated the immune system of mice, promoting the maturation of antigen-presenting cells and the activation of T lymphocytes. The nanoparticles exhibited good biosafety and significant tumor inhibition in both orthotopic and patient-derived xenograft (PDX) models. These novel nanoparticles provide a promising modality for the treatment of highly aggressive cancers and a valuable avenue for future clinical applications.
期刊介绍:
Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.