Ramesh L. Sawant, Manisha R. Sawant, Jyoti B. Wadekar, Ganesh D. Barkade, Havagiray R. Chitme
{"title":"1,3-噻唑烷-4- ones：铜镍氧化物双金属纳米颗粒催化合成、抗癌潜力及分子模拟研究","authors":"Ramesh L. Sawant, Manisha R. Sawant, Jyoti B. Wadekar, Ganesh D. Barkade, Havagiray R. Chitme","doi":"10.1134/S1070427223601924","DOIUrl":null,"url":null,"abstract":"<p>Cancer is a leading cause of death worldwide. Inhibiting mitosis is the most effective clinical technique for cancer treatment. In this investigation, copper-nickel oxide nanoparticles synthesized by electrochemical synthesis and analysed by UV-visible spectrophotometer (UV 1800 Shimadzu), a Fourier transform infrared spectrophotometer (FTIR Affinity 1 Shimadzu), a thermogravimetric analyser (TGA 50 Thermoanalyzer Shimadzu), a high-end X-ray diffractometer, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), and transmission electron microscopy elected area electron diffraction (TEM-SAED) techniques. The calcinated copper nickel oxide nanoparticles were used successfully as a catalyst to synthesis of 2-(2-substituted-4-oxothiazolidin-3-yl)-1,9-dihydro-purin-6-ones. The title compounds were characterized by melting point, IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and LC-HRMS/MS spectroscopy. Using Sulforhodamine B (SRB) test, all newly synthesized compounds were evaluated <i>in vitro</i> for anti-cancer, anti-inflammatory, antioxidant, and angiogenesis activities. The compounds GB-6, GB-8, GB-10 exhibited significant in vitro anti-inflammatory activityin the range of IC<sub>50</sub>:179.65-194.59 μg/ml as compared with aceclofenac (IC<sub>50</sub>: 191.19 μg/mL) and the antioxidant activity by DPPH radical scavenging assay the compounds GB-6 (IC<sub>50</sub>: 11.96 μg/mL), GB-8 (IC<sub>50</sub>:10.67 μg/mL) and GB-10 (IC<sub>50</sub>: 9.08 μg/mL) exhibited excellent radical scavenging activities compared to ascorbic acid (IC<sub>50</sub>:13.04 μg/mL) and by the KMnO<sub>4</sub> radical scavenging assay the compounds GB-2 (IC<sub>50</sub>: 15.33 μg/mL), GB-4 (IC<sub>50</sub>: 23.60 μg/mL), GB-8 (IC<sub>50</sub>: 24.93 μg/mL), GB-10 (IC<sub>50</sub>: 24.96 μg/mL) exhibited good radical scavenging activities compared to ascorbic acid (IC<sub>50</sub>: 26.55 μg/mL). Further development of anticancer drugs may be enabled by the discovery of related compounds to the anticancer agent, such as compound (GB-6), compound (GB-8), and compound (GB-10) as polo-like kinase 1 inhibitors.</p>","PeriodicalId":757,"journal":{"name":"Russian Journal of Applied Chemistry","volume":"97 12","pages":"899 - 918"},"PeriodicalIF":0.6000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"1,3-Thiazolidine-4-Ones: Copper Nickel Oxide Bimetallic Nanoparticle Catalysed Synthesis, Anticancer Potential and Molecular Modeling Studies\",\"authors\":\"Ramesh L. Sawant, Manisha R. Sawant, Jyoti B. Wadekar, Ganesh D. Barkade, Havagiray R. Chitme\",\"doi\":\"10.1134/S1070427223601924\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Cancer is a leading cause of death worldwide. Inhibiting mitosis is the most effective clinical technique for cancer treatment. In this investigation, copper-nickel oxide nanoparticles synthesized by electrochemical synthesis and analysed by UV-visible spectrophotometer (UV 1800 Shimadzu), a Fourier transform infrared spectrophotometer (FTIR Affinity 1 Shimadzu), a thermogravimetric analyser (TGA 50 Thermoanalyzer Shimadzu), a high-end X-ray diffractometer, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), and transmission electron microscopy elected area electron diffraction (TEM-SAED) techniques. The calcinated copper nickel oxide nanoparticles were used successfully as a catalyst to synthesis of 2-(2-substituted-4-oxothiazolidin-3-yl)-1,9-dihydro-purin-6-ones. The title compounds were characterized by melting point, IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and LC-HRMS/MS spectroscopy. Using Sulforhodamine B (SRB) test, all newly synthesized compounds were evaluated <i>in vitro</i> for anti-cancer, anti-inflammatory, antioxidant, and angiogenesis activities. The compounds GB-6, GB-8, GB-10 exhibited significant in vitro anti-inflammatory activityin the range of IC<sub>50</sub>:179.65-194.59 μg/ml as compared with aceclofenac (IC<sub>50</sub>: 191.19 μg/mL) and the antioxidant activity by DPPH radical scavenging assay the compounds GB-6 (IC<sub>50</sub>: 11.96 μg/mL), GB-8 (IC<sub>50</sub>:10.67 μg/mL) and GB-10 (IC<sub>50</sub>: 9.08 μg/mL) exhibited excellent radical scavenging activities compared to ascorbic acid (IC<sub>50</sub>:13.04 μg/mL) and by the KMnO<sub>4</sub> radical scavenging assay the compounds GB-2 (IC<sub>50</sub>: 15.33 μg/mL), GB-4 (IC<sub>50</sub>: 23.60 μg/mL), GB-8 (IC<sub>50</sub>: 24.93 μg/mL), GB-10 (IC<sub>50</sub>: 24.96 μg/mL) exhibited good radical scavenging activities compared to ascorbic acid (IC<sub>50</sub>: 26.55 μg/mL). Further development of anticancer drugs may be enabled by the discovery of related compounds to the anticancer agent, such as compound (GB-6), compound (GB-8), and compound (GB-10) as polo-like kinase 1 inhibitors.</p>\",\"PeriodicalId\":757,\"journal\":{\"name\":\"Russian Journal of Applied Chemistry\",\"volume\":\"97 12\",\"pages\":\"899 - 918\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Applied Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070427223601924\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Applied Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070427223601924","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Cancer is a leading cause of death worldwide. Inhibiting mitosis is the most effective clinical technique for cancer treatment. In this investigation, copper-nickel oxide nanoparticles synthesized by electrochemical synthesis and analysed by UV-visible spectrophotometer (UV 1800 Shimadzu), a Fourier transform infrared spectrophotometer (FTIR Affinity 1 Shimadzu), a thermogravimetric analyser (TGA 50 Thermoanalyzer Shimadzu), a high-end X-ray diffractometer, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), and transmission electron microscopy elected area electron diffraction (TEM-SAED) techniques. The calcinated copper nickel oxide nanoparticles were used successfully as a catalyst to synthesis of 2-(2-substituted-4-oxothiazolidin-3-yl)-1,9-dihydro-purin-6-ones. The title compounds were characterized by melting point, IR, 1H NMR, 13C NMR and LC-HRMS/MS spectroscopy. Using Sulforhodamine B (SRB) test, all newly synthesized compounds were evaluated in vitro for anti-cancer, anti-inflammatory, antioxidant, and angiogenesis activities. The compounds GB-6, GB-8, GB-10 exhibited significant in vitro anti-inflammatory activityin the range of IC50:179.65-194.59 μg/ml as compared with aceclofenac (IC50: 191.19 μg/mL) and the antioxidant activity by DPPH radical scavenging assay the compounds GB-6 (IC50: 11.96 μg/mL), GB-8 (IC50:10.67 μg/mL) and GB-10 (IC50: 9.08 μg/mL) exhibited excellent radical scavenging activities compared to ascorbic acid (IC50:13.04 μg/mL) and by the KMnO4 radical scavenging assay the compounds GB-2 (IC50: 15.33 μg/mL), GB-4 (IC50: 23.60 μg/mL), GB-8 (IC50: 24.93 μg/mL), GB-10 (IC50: 24.96 μg/mL) exhibited good radical scavenging activities compared to ascorbic acid (IC50: 26.55 μg/mL). Further development of anticancer drugs may be enabled by the discovery of related compounds to the anticancer agent, such as compound (GB-6), compound (GB-8), and compound (GB-10) as polo-like kinase 1 inhibitors.
期刊介绍：
Russian Journal of Applied Chemistry (Zhurnal prikladnoi khimii) was founded in 1928. It covers all application problems of modern chemistry, including the structure of inorganic and organic compounds, kinetics and mechanisms of chemical reactions, problems of chemical processes and apparatus, borderline problems of chemistry, and applied research.
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