亚磷膦基CuI配合物：在1,3-偶极叠氮-炔环加成和a3偶联反应中的应用

IF 2.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

New Journal of Chemistry Pub Date : 2025-04-08 DOI:10.1039/D5NJ00379B

Rani Gourkhede and Maravanji S. Balakrishna

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引用次数: 0

摘要

本文报道了以亚磷酸氨基膦配体为配体的[CuX{(PPh2CH2Ph2PNAr*)-κ2-P,N}] （2 X = Cl, 3 X = Br, 4 X = I）型CuI配合物的合成、结构表征和催化研究(1)。配合物4在1,3-偶极叠氮-炔环加成反应（CuAAC）和a3偶联反应中表现出优异的催化活性。催化反应在室温下无溶剂环境下进行。值得注意的是，一步a3偶联方案使pargyline的合成成为可能，这是一种具有临床意义的药物，产率为68%。

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Iminophosphorano–phosphine based CuI complexes: utility in 1,3-dipolar azide–alkyne cycloaddition and A3-coupling reaction†

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Iminophosphorano–phosphine based CuI complexes: utility in 1,3-dipolar azide–alkyne cycloaddition and A3-coupling reaction†

This manuscript reports the synthesis, structural characterization and catalytic investigations of Cu^I complexes of the type [CuX{(PPh₂CH₂Ph₂PNAr*)-κ²-P,N}] (2 X = Cl, 3 X = Br, 4 X = I) featuring an iminophosphorano–phosphine ligand (1). The complex 4 showed exceptional catalytic activity in 1,3-dipolar azide–alkyne cycloaddition (CuAAC) and A³-coupling reactions. The catalytic reactions were performed at room temperature under solvent-free conditions in an environmentally benign manner. Notably, a one-step A³-coupling protocol enabled the synthesis of pargyline, a clinically significant drug in 68% yield.