杂合子-地中海贫血的血液学比率和细胞因子谱

IF 1.8 Q3 HEMATOLOGY
Ana Carolina Marques Ciceri , Laura Eduarda de Oliveira , Ana Luísa Richter , José Antonio Mainardi de Carvalho , Maylla Rodrigues Lucena , Guilherme Wataru Gomes , Maria Stella Figueiredo , Magnun Nueldo Nunes dos Santos , Vera Lúcia Nascimento Blaia-D'Avila , Rodolfo Delfini Cançado , Elvira Maria Guerra-Shinohara , Clóvis Paniz
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引用次数: 0

摘要

β-地中海贫血的定义是血红蛋白中β-珠蛋白链合成减少或完全缺乏,导致溶血性贫血。杂合子β-地中海贫血,也称为β-地中海贫血性状(hBTh),是这种贫血的最轻微形式,通常在携带者中不会引起症状。然而,它可能导致免疫系统的变化,包括白细胞、中性粒细胞和淋巴细胞总数的增加。目的评价β-地中海贫血特征携带者的中性粒细胞/淋巴细胞、衍生性中性粒细胞/淋巴细胞、淋巴细胞/单核细胞、血小板/淋巴细胞、中性粒细胞/血小板比率、全身免疫-炎症指数、全身炎症反应指数、中性粒细胞/自然杀伤细胞比率(NNKR)和炎症因子等免疫和炎症指标。方法采用回顾性观察研究方法,选取50例β-地中海贫血个体和100例健康对照。结果携带者白细胞、中性粒细胞、网织细胞计数及白细胞介素6水平均高于对照组。值得注意的是,β-地中海贫血性状组中性粒细胞/血小板比率、中性粒细胞/淋巴细胞比率和衍生性中性粒细胞/淋巴细胞比率均升高,全身免疫炎症和全身炎症反应指标均高于对照组。结论血液学指标显示β-地中海贫血特征具有更明显的炎症特征。因此,这些比率是潜在的具有成本效益和易于应用的监测β-地中海贫血患者特征的标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hematological ratios and cytokine profiles in heterozygous beta-thalassemia

Introduction

β-Thalassemia is defined by a reduced or complete absence of β-globin chain synthesis in hemoglobin, leading to hemolytic anemia. Heterozygous β-thalassemia, also known as β-thalassemia trait (hBTh), the mildest form of this anemia, typically does not cause symptoms in carriers. However, it may lead to changes in the immune system, including an increase in total leukocyte, neutrophil, and lymphocyte counts.

Objective

This study aimed to evaluate various immune and inflammation markers, including neutrophil/lymphocyte, derived neutrophil/lymphocyte, lymphocyte/monocyte, platelet/lymphocyte, neutrophil/platelet ratios, systemic immune-inflammation index, systemic inflammation response index, neutrophil/natural killer cell ratio (NNKR), and inflammatory cytokines in β-thalassemia trait carriers.

Method

A retrospective observational study was conducted, including 50 β-thalassemia trait individuals and 100 healthy controls.

Results

Leukocyte, neutrophil and reticulocyte counts, and interleukin 6 levels were higher in carriers compared to controls. Notably, the β-thalassemia trait group had increased neutrophil/platelet, neutrophil/lymphocyte and derived neutrophil/lymphocyte ratios, and the systemic immune-inflammation and systemic inflammation response indexes were higher compared to the controls.

Conclusions

β-thalassemia trait shows a more pronounced inflammatory profile as indicated by hematological ratios. These ratios, therefore are potentially cost-effective and easily applicable markers for monitoring patients with the β-thalassemia trait.
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来源期刊
CiteScore
2.40
自引率
4.80%
发文量
1419
审稿时长
30 weeks
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