与空气传播的SARS-CoV-2检测相关的COVID-19患者变量

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-04-22 DOI:10.1016/j.jiph.2025.102785

Joan Truyols-Vives , Gabriel Escarrer-Garau , Laura Arbona-González , Núria Toledo-Pons , Jaume Sauleda-Roig , Miguel David Ferrer , Pablo Arturo Fraile-Ribot , Antonio Doménech-Sánchez , Herme García-Baldoví , Ernest Sala-Llinàs , Antoni Colom-Fernández , Josep Mercader-Barceló

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引用次数: 0

摘要

背景了解影响环境SARS-CoV-2负荷的COVID-19患者特征对改善感染风险管理至关重要。在本研究中，我们分析了患者变量对空气传播的SARS-CoV-2基因组检测的影响。方法通过3项独立研究招募69名COVID-19患者，采用液滴数字PCR技术在个别病房对空气传播的SARS-CoV-2基因组进行评估。结果在双因素分析中，肥胖、慢性呼吸系统疾病、入院、采样和出院时均为肺炎、淋巴细胞计数较低的患者空气中检测到SARS-CoV-2的几率明显较高。未发现空气中SARS-CoV-2检测与症状存在或持续时间之间存在显著关联，也未发现与空气采样前最近一次鼻咽PCR检测阳性结果之间存在显著关联。在多变量分析中，最佳拟合模型包括患者年龄、入院类型和症状持续时间。在多因素分析中，患者年龄对空气中检测到SARS-CoV-2的风险有显著影响。结论本研究结果突出了个体对SARS-CoV-2感染反应的差异性，提示与COVID-19严重程度、症状学和免疫能力相关的因素影响空气中SARS-CoV-2的检测。我们的研究结果可能支持在医疗机构中开发更精确的预防措施。

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COVID-19 patient variables associated with the detection of airborne SARS-CoV-2

Background

Understanding the COVID-19 patient characteristics that impact environmental SARS-CoV-2 load is essential for improving infection risk management. In this study, we analyzed the influence of patient variables on airborne SARS-CoV-2 genome detection.

Methods

Sixty-nine COVID-19 patients were recruited across three independent studies with airborne SARS-CoV-2 genome assessed in individual hospital rooms using droplet digital PCR.

Results

In the bivariate analysis, the odds of airborne SARS-CoV-2 detection were significantly higher for patients with obesity, chronic respiratory diseases, pneumonia at admission, sampling, and discharge, and lower lymphocytes count. No significant associations were found between airborne SARS-CoV-2 detection and symptoms presence or duration, nor with the results of the most recent positive nasopharyngeal PCR test prior to air sampling. In the multivariate analysis, the best-fit model included patient age, type of admission, and symptoms duration. Patient age significantly contributed to the risk of airborne SARS-CoV-2 detection in the multivariate analysis.

Conclusions

Our findings highlight the variability in individual responses to SARS-CoV-2 infection and suggest that factors linked to COVID-19 severity, symptomatology, and immunocompetence influence the airborne SARS-CoV-2 detection. Our results may support the development of more precise preventive measures in healthcare settings.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.