生活方式因素、中医体质类型与女性阴道微生物群健康的关系：一项病例对照研究

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

European Journal of Integrative Medicine Pub Date : 2025-04-09 DOI:10.1016/j.eujim.2025.102476

Jiali Wei , Guohua Wang , Zehao Zheng , Yue Qiu , Xue Pan , Xinyu Li , Mei Han

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引用次数: 0

摘要

阴道炎是一种受多种因素影响的女性生殖道炎症，包括激素水平、生活习惯和个体易感性。在中医理论中，不同的体质类型会影响阴道炎的发生和发展，因为它们决定了一个人体内的阴阳、气和血的平衡。本研究旨在探讨生活方式因素、中医体质类型与阴道微生态异常的相关性。方法于2024年8月至10月在北京中医药大学第三附属医院进行病例对照研究，纳入年龄在18-45岁、有性行为史的女性。暴露变量包括年龄、生活习惯和中医体质类型，结果变量集中于阴道微生态异常。使用逻辑回归和最小绝对收缩和选择算子（LASSO）回归评估相关性，结果以比值比（ORs）和95%置信区间（ci）报告。结果本研究确定了阴道微生态失衡的几个重要危险因素。单因素分析显示，异常组（n = 334）与正常组（n = 111）在生殖感染评分、久坐时间、肉类和甜点消费、中医体质类型等方面存在差异。多因素logistic回归证实生殖感染评分(OR = 1.2454, P <；0.0001)和久坐时间（OR = 1.3501, P = 0.0002）是主要因素，而肉类消费的风险几乎翻了一番（OR = 1.9941, P = 0.0230）。湿热体质（DHC）（OR = 6.6673, P = 0.0212）和气虚体质（QDC）（OR = 3.9269, P = 0.0420）与阴道菌群异常风险显著升高相关。LASSO回归分析进一步强调了生殖感染评分和久坐时间在微生态失衡中的关键作用。结论生殖感染评分和久坐时间是导致阴道微生态失衡的重要因素，而饮食习惯和中医体质类型（如DHC和QDC）进一步影响阴道微生态失衡的风险。这些结果为阴道微生态的多因素性质提供了有价值的见解，并建议解决这些因素可以改善预防保健和管理。

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Association between lifestyle factors, traditional Chinese medicine constitution types and vaginal microbiota health in women: A case-control study

Introduction

Vaginitis is an inflammatory condition of the female reproductive tract influenced by multiple factors, including hormone levels, lifestyle habits, and individual predispositions. In Traditional Chinese Medicine (TCM) theory, different constitution types can influence the onset and progression of vaginitis, as they determine an individual's internal balance of Yin and Yang, Qi, and Blood. This study aims to explore the correlation between lifestyle factors, TCM constitution types, and vaginal microecological abnormalities.

Methods

A case-control study was conducted at the Third Affiliated Hospital of Beijing University of Chinese Medicine between August and October 2024, involving women aged 18–45 with a history of sexual activity. The exposure variables encompassed age, lifestyle habits, and TCM constitution types, while the outcome variable focused on vaginal microecological abnormalities. Associations were assessed using logistic regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression, with results reported as odds ratios (ORs) and 95 % confidence intervals (CIs).

Results

This study identified several significant risk factors for vaginal microecological imbalance. Univariate analysis showed differences between the abnormal (n = 334) and normal groups (n = 111) in reproductive infection score, sedentary hours, meat and dessert consumption, and TCM constitution types. Multivariate logistic regression confirmed reproductive infection score (OR = 1.2454, P < 0.0001) and sedentary hours (OR = 1.3501, P = 0.0002) as key contributors, with meat consumption nearly doubling the risk (OR = 1.9941, P = 0.0230). Additionally, dampness-heat constitution (DHC) (OR = 6.6673, P = 0.0212) and qi-deficiency constitution (QDC) (OR = 3.9269, P = 0.0420) were associated with significantly higher risks of abnormal vaginal flora. LASSO regression analysis further emphasized the critical roles of reproductive infection score and sedentary hours in driving microecological imbalance.

Conclusion

Reproductive infection score and sedentary hours are significant contributors to vaginal microecological imbalance, while dietary habits and TCM constitution types, such as DHC and QDC, further influence the risk. These results provide valuable insights into the multifactorial nature of vaginal microecology and suggest that addressing these factors could improve preventive care and management.

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来源期刊

European Journal of Integrative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

4.70

自引率

4.00%

发文量

102

审稿时长

33 days

期刊介绍： The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education. EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians. The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.