大流行前精神疾病、疾病特异性多基因评分和COVID-19大流行期间的酒精消费模式

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-05-08 DOI:10.1016/j.jpsychires.2025.05.016

Lea Arregui Nordahl Christoffersen , Liam Quinn , Thorsten Brodersen , Isabella Loft , Bitten Aagaard Jensen , Christian Erikstrup , Christina Mikkelsen , DBDS Genetic Consortium, Erik Sørensen , Henry R. Kranzler , Kathrine Agergård Kaspersen , Maria Didriksen , Sisse Rye Ostrowski , Thomas Werge , Dorte Helenius , Ole B. Pedersen

{"title":"大流行前精神疾病、疾病特异性多基因评分和COVID-19大流行期间的酒精消费模式","authors":"Lea Arregui Nordahl Christoffersen , Liam Quinn , Thorsten Brodersen , Isabella Loft , Bitten Aagaard Jensen , Christian Erikstrup , Christina Mikkelsen , DBDS Genetic Consortium, Erik Sørensen , Henry R. Kranzler , Kathrine Agergård Kaspersen , Maria Didriksen , Sisse Rye Ostrowski , Thomas Werge , Dorte Helenius , Ole B. Pedersen","doi":"10.1016/j.jpsychires.2025.05.016","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Pre-pandemic psychiatric disorders have been associated with elevated alcohol consumption during the COVID-19 pandemic, raising concerns about associated morbidity and mortality; however, insight into the mechanisms is lacking.</div></div><div><h3>Methods</h3><div>In this prospective cohort study with multiple follow-ups of 27,208 participants from the Danish Blood Donor Study, the potential genetic influence on the associations of pre-pandemic alcohol use disorders (AUD) and major depressive disorder (MDD) with pandemic alcohol consumption patterns was assessed in Poisson regression models, using polygenic scores (PGS). Information on pre-pandemic psychiatric disorders was obtained from Danish national health registers, while information on alcohol consumption was obtained through questionnaires.</div></div><div><h3>Results</h3><div>Adjustment for PGSs did not impact the association of pre-pandemic AUD with alcohol consumption patterns during the COVID-19 pandemic at any time points (e.g., unadjusted [B = 0.68; 95 %CI: 0.52; 0.84] vs. adjusted for AUD PGS [B = 0.66; 95 %CI: 0.50; 0.82]. However, higher AUD PGSs were associated with higher alcohol consumption among individuals without pre-pandemic AUD. Pre-pandemic MDD was unrelated to alcohol consumption patterns during the COVID-19 pandemic in all analyses.</div></div><div><h3>Conclusion</h3><div>Genetic liability to AUD was associated with increased alcohol consumption during the COVID-19 pandemic but only among individuals without pre-pandemic AUD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 163-173"},"PeriodicalIF":3.7000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pre-pandemic psychiatric disorders, disease specific polygenic scores, and alcohol consumption patterns during the COVID-19 pandemic\",\"authors\":\"Lea Arregui Nordahl Christoffersen , Liam Quinn , Thorsten Brodersen , Isabella Loft , Bitten Aagaard Jensen , Christian Erikstrup , Christina Mikkelsen , DBDS Genetic Consortium, Erik Sørensen , Henry R. Kranzler , Kathrine Agergård Kaspersen , Maria Didriksen , Sisse Rye Ostrowski , Thomas Werge , Dorte Helenius , Ole B. Pedersen\",\"doi\":\"10.1016/j.jpsychires.2025.05.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Pre-pandemic psychiatric disorders have been associated with elevated alcohol consumption during the COVID-19 pandemic, raising concerns about associated morbidity and mortality; however, insight into the mechanisms is lacking.</div></div><div><h3>Methods</h3><div>In this prospective cohort study with multiple follow-ups of 27,208 participants from the Danish Blood Donor Study, the potential genetic influence on the associations of pre-pandemic alcohol use disorders (AUD) and major depressive disorder (MDD) with pandemic alcohol consumption patterns was assessed in Poisson regression models, using polygenic scores (PGS). Information on pre-pandemic psychiatric disorders was obtained from Danish national health registers, while information on alcohol consumption was obtained through questionnaires.</div></div><div><h3>Results</h3><div>Adjustment for PGSs did not impact the association of pre-pandemic AUD with alcohol consumption patterns during the COVID-19 pandemic at any time points (e.g., unadjusted [B = 0.68; 95 %CI: 0.52; 0.84] vs. adjusted for AUD PGS [B = 0.66; 95 %CI: 0.50; 0.82]. However, higher AUD PGSs were associated with higher alcohol consumption among individuals without pre-pandemic AUD. Pre-pandemic MDD was unrelated to alcohol consumption patterns during the COVID-19 pandemic in all analyses.</div></div><div><h3>Conclusion</h3><div>Genetic liability to AUD was associated with increased alcohol consumption during the COVID-19 pandemic but only among individuals without pre-pandemic AUD.</div></div>\",\"PeriodicalId\":16868,\"journal\":{\"name\":\"Journal of psychiatric research\",\"volume\":\"187 \",\"pages\":\"Pages 163-173\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of psychiatric research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022395625003061\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022395625003061","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

摘要

背景：在COVID-19大流行期间，大流行前精神疾病与饮酒增加有关，引发了对相关发病率和死亡率的担忧；然而，缺乏对其机制的深入了解。方法在这项前瞻性队列研究中，对来自丹麦献血者研究的27,208名参与者进行了多次随访，使用多基因评分（PGS），在泊松回归模型中评估了大流行酒精使用障碍（AUD）和重度抑郁症（MDD）与大流行酒精消费模式之间关联的潜在遗传影响。关于大流行前精神疾病的信息是从丹麦国家健康登记册获得的，而关于酒精消费的信息是通过问卷获得的。结果：调整pgs不影响大流行前AUD与COVID-19大流行期间任何时间点酒精消费模式的关联(例如，未经调整的[B = 0.68；95% ci: 0.52；0.84]与调整后的AUD PGS比较[B = 0.66；95% ci: 0.50；0.82]。然而，在没有大流行前AUD的个体中，较高的AUD pgs与较高的酒精消费量相关。在所有分析中，大流行前重度抑郁症与COVID-19大流行期间的饮酒模式无关。结论：在COVID-19大流行期间，AUD的遗传易感性与饮酒增加有关，但仅适用于没有大流行前AUD的个体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Pre-pandemic psychiatric disorders, disease specific polygenic scores, and alcohol consumption patterns during the COVID-19 pandemic

Background

Pre-pandemic psychiatric disorders have been associated with elevated alcohol consumption during the COVID-19 pandemic, raising concerns about associated morbidity and mortality; however, insight into the mechanisms is lacking.

Methods

In this prospective cohort study with multiple follow-ups of 27,208 participants from the Danish Blood Donor Study, the potential genetic influence on the associations of pre-pandemic alcohol use disorders (AUD) and major depressive disorder (MDD) with pandemic alcohol consumption patterns was assessed in Poisson regression models, using polygenic scores (PGS). Information on pre-pandemic psychiatric disorders was obtained from Danish national health registers, while information on alcohol consumption was obtained through questionnaires.

Results

Adjustment for PGSs did not impact the association of pre-pandemic AUD with alcohol consumption patterns during the COVID-19 pandemic at any time points (e.g., unadjusted [B = 0.68; 95 %CI: 0.52; 0.84] vs. adjusted for AUD PGS [B = 0.66; 95 %CI: 0.50; 0.82]. However, higher AUD PGSs were associated with higher alcohol consumption among individuals without pre-pandemic AUD. Pre-pandemic MDD was unrelated to alcohol consumption patterns during the COVID-19 pandemic in all analyses.

Conclusion

Genetic liability to AUD was associated with increased alcohol consumption during the COVID-19 pandemic but only among individuals without pre-pandemic AUD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;